Journal of Neurology

, Volume 239, Issue 5, pp 284–286 | Cite as

The effect of a synthetic GnRH analogue on catamenial epilepsy: a study in ten patients

  • J. Bauer
  • L. Wild
  • D. Flügel
  • H. Stefan
Original Communications


Ten female patients suffering from catamenial epilepsy were treated with a synthetic analogue of the gonadotrophin releasing hormone (GnRH) in additon to antiepileptic drugs. Three of the patients became seizure free, in four patients seizure frequency decreased and in one patient seizures were of shorter duration. In only two of the patients was there no therapeutic effect. Adverse effects, including hot flushes, headache and increase in weight, were noticed in eight patients. These results support the hypothesis that treatment with a synthetic GnRH analogue might be helpful in patients with intractable catamenial epilepsies.

Key words

Catamenial epilepsy Seizure clustering Intractable epilepsy Gonadotrophin releasing hormone 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • J. Bauer
    • 1
  • L. Wild
    • 2
  • D. Flügel
    • 1
  • H. Stefan
    • 1
  1. 1.Neurologische Klinik der Universität Erlangen-NürnbergErlangenGermany
  2. 2.Frauenklinik der Universität Erlangen-NürnbergErlangenGermany

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