Springer Seminars in Immunopathology

, Volume 21, Issue 2, pp 135–145 | Cite as

Anterior uveitis: clinical and research perspectives

  • James T. Rosenbaum
  • Tammy M. Martin
  • Stephen R. Planck
Article

Keywords

Internal Medicine Uveitis Anterior Uveitis Research Perspective 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adamus G, Amundson D, Vainiene M, Ariail K, Machnicki M, Weinberg A (1996) Myelin basic protein specific T-helper cells induce experimental anterior uveitis. J Neurosci Res 44:513Google Scholar
  2. 2.
    Allen JB, McGahan MC, Ferrell JB, Adler KB, Fleisher LN (1996) Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis. Exp Eye Res 62:21Google Scholar
  3. 3.
    Aoki K (1978) A study of endotoxemia in ulcerative colitis and Crohn's disease. I. Cli. Acta Med Okayama 32:147Google Scholar
  4. 4.
    Baggia S, Lyons J, Angell E, Barkhhizen A, Han YB, Planck SR, Taurog JD, Rosenbaum JT (1997) A novel model of bacterially-induced acute anterior uveitis in rats the lack of effect from HLA B27 expression. J Invest Med 45:295Google Scholar
  5. 5.
    Bora NS, Kim MC, Kabeer NH, Simpson SC, Tandhasetti MT, Cirrito TP, Kaplan AD, Kaplan HJ (1995) Experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci 36:1056Google Scholar
  6. 6.
    Brewerton DA, Caffrey M, Nicholls A, Walter D, James DCO (1973) Acute anterior uveitis and HLA B27. Lancet 11:994Google Scholar
  7. 7.
    Broekhuyse RM, Kuhlmann ED, Winkens HJ, Van Vugt AH (1991) Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium. Exp Eye Res 52:465Google Scholar
  8. 8.
    Broekhuyse RM, Kuhlmann ED, Winkens HJ (1996) Experimental melanin-protein induced uveitis (EMIU) is the sole type of uveitis evoked by a diversity of ocular melanin preparations and melanin-derived soluble polypeptides. Japan J Ophthalmol 40:459Google Scholar
  9. 9.
    rosnan CF, Litwak MS, Schroeder CE, Selmaj K, Raine CS, Arezzo JC (1989) Preliminary studies of cytokine-induced functional effects on the visual pathways in the rabbit. J Neuroimmunol 25:227Google Scholar
  10. 10.
    Caspi RR, Grubbs BG, Chan C-C, Chader GJ, Wiggert B (1992) Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. J Immunol 148:2384Google Scholar
  11. 11.
    Chan C-C, Hikita N, Dastgheib K, Whitcup S, Gery U, Nussenblatt RB (1994) Experimental melanin-protein-induced uveitis in the Lewis rat. Ophthalmology 101:1275Google Scholar
  12. 12.
    Cousins SW, Guss RB, Howes EL Jr, Rosenbaum JT (1984) Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology. Exp Eye Res 39:665Google Scholar
  13. 13.
    D'Alessandro LP, Forster DJ, Rao NA (1991) Anterior uveitis and hypopyon. Am J Ophthalmol 112:317Google Scholar
  14. 14.
    Darrell RW, Wagener HP, Kurland LT (1962) Epidemiology of uveitis, incidence and prevalence in a small urban community. Arch Ophthalmol 68:502Google Scholar
  15. 15.
    De Vos AF, Van Haren MA, Verhagen C, Hoekzema R, Kijlstra A (1995) Systemic anti-tumor necrosis factor antibody treatment exacerbates endotoxin-induced uveitis in the rat. Exp Eye Res 61:667Google Scholar
  16. 16.
    De Vos AF, Klaren VNA, Kijlstra A (1994) Expression of multiple cytokines and IL-IRA in the uvea and retina during endotoxin-induced uveitis in the rat. Invest Ophthalmol Vis Sci 35:3873Google Scholar
  17. 17.
    Ebringer A, Baines M, Ptaszynska T (1985) Spondyloarthritis, uveitis, HLA-1327 andKlebsiella. Immunol Rev 86:101Google Scholar
  18. 18.
    Elliot M, Maim R, Feldman M, Long-Fox A, Charles P, Bijl H, Woody J (1994) Repeated therapy with monoclonal antibody to tumour necrosis factor a (cA2) in patients with rheumatoid arthritis. Lancet 344:1125Google Scholar
  19. 19.
    Feltkamp TEW (1985) HLA B27, acute anterior uveitis, and ankylosing spondylitis. Adv Inflammation Res 9:211Google Scholar
  20. 20.
    Ferguson T, Fletcher S, Herndon J, Griffith T (1995) Neuropeptides modulate immune deviation induced via the anterior chamber of the eye. J Immunol 155:1746Google Scholar
  21. 21.
    Ferrick MR, Thurau SR, Oppenheim MH, Herbort CP, Ni M, Zachariae CO, Matsushima K, Chan C-C (1991) Ocular inflammation stimulated by intravitreal interleukin-8 and interleukin-1. Invest Ophthalmol Vis Sci 32:1534Google Scholar
  22. 22.
    Fleisher LN, Ferrell JB, Smith MG, McGahan MC (1991) Lipid mediators of tumor necrosis factor-alpha induced uveitis. Invest Ophthalmol Vis Sci 32:2393Google Scholar
  23. 23.
    Goreau O, Bellot J, Thillaye B, Courtois Y, de Kozak Y (1995) Increased nitric oxide production in endotoxin-induced uveitis. J Immunol 154:6518Google Scholar
  24. 24.
    Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA (1995) Fas-ligand induced apoptosis as a mechanism of immune privilege. Science 270:1189Google Scholar
  25. 25.
    Guex-Crosier Y, Wittwer AJ, Roberge FG (1996) Intraocular production of a cytokine (CINC) responsible for neutrophil infiltration in endotoxin-induced uveitis. Br J Ophthalmol 80:649Google Scholar
  26. 26.
    Hammer RE, Maika SD, Richardson JA, Tang J-P, Taurog JD (1990) Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta-2 microglobulin: an animal model of HLA-B27-associated human disorders. Cell 63:1099Google Scholar
  27. 27.
    Hill JL, Yu DT (1987) Development of an experimental animal model for reactive arthritis induced byYersinia enterocolitica infection. Infect Immun 55:721Google Scholar
  28. 28.
    Hoekzema R, Murray PI, Haren MAC van, Helle M, Kijlstra A (1991) Analysis of interleukin-6 in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 32:88Google Scholar
  29. 29.
    Howes EL Jr, Wong KL, Hartiala KT, Webster RO, Rosenbaum JT (1985) Complement and polymorphonuclear leukocytes do not determine the vascular permeability induced by intraocular LPS. Am J Pathol 118:35Google Scholar
  30. 30.
    Howes EL Jr, Goldyne ME, Perez HD, Goldstein IM, Rosenbaum JT (1985) LPS tolerance inhibits eye inflammation. I. Reduced immune complex or LPS effects. Arch Ophthalmol 103:257Google Scholar
  31. 31.
    Kanagawa T, Matsuda S, Mikawa Y, Kogiso M, Nagasawa H, Himeno K, Hashimoto Y, Mimura Y (1996) Role of ICAM-1 and LFA-1 in endotoxin-induced uveitis in mice. Jpn J Ophthalmol 40:174Google Scholar
  32. 32.
    Kasner L, Chan C-C, Whitcup SM, Gery I (1993) The paradoxical effect of tumor necrosis factor alpha (TNFα) in endotoxin-induced uveitis [Abstract]. Invest Ophthalmol Vis Sci 34:2911Google Scholar
  33. 33.
    Khare SD, Luthra HS, David CS (1995) Spontaneous inflammatory arthritis in HLA-1327 transgenic mice lacking beta2-microglobulin: a model of human spondyloarthropathies. J Exp Med 182:1153Google Scholar
  34. 34.
    Kogiso M, Tanouchi Y, Mimura Y, Nagasawa H, Himeno K (1992) Endotoxin-induced uveitis in mice. 1. Induction of uveitis and role of T lymphocytes. Jpn J Ophthalmol 36:281Google Scholar
  35. 35.
    Kulkarni PS, Mancino M (1993) Studies on intraocular inflammation produced by intravitreal human interleukins in rabbits. Exp Eye Res 56:275Google Scholar
  36. 36.
    Labow MA, Norton CR, Rumberger JM etal (1994) Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1:709Google Scholar
  37. 37.
    Li Q, Peng B, Whitcup SM, Jang SU, Chan C-C (1995) Endotoxin induced uveitis in the mouse: susceptibility and genetic control. Exp Eye Res 61:629Google Scholar
  38. 38.
    Lyons JL, Rosenbaum JT (1997) Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy. Arch Ophthalmol 115:61Google Scholar
  39. 39.
    Maksymowych WP, Russell AS (1995) Polymorphism in the LMP2 gene influences the relative risk for acute anterior uveitis in unselected patients with ankylosing spondylitis. Clin Invest Med 18:42Google Scholar
  40. 40.
    Mandai M, Yoshimma N, Yoshida M, Iwaki M, Honda Y (1994) The role of nitric oxide synthase in endotoxin-induced uveitis: effects ofN G-nitro L-arginine. Invest Ophthalmol Vis Sci 35:3673Google Scholar
  41. 41.
    Mielants H, Veys EM, Cuvelier C, De Vos M, Botelberghe L (1985) HLA-B27-related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27-related arthritis. J Rheumatol 12:294Google Scholar
  42. 42.
    Murray PI, Hoekzema R, Haren MAC van, Hon FD de, Kijlstra A (1990) Aqueous humor interleukin-6 levels in uveitis. Invest Ophthalmol Vis Sci 31:917Google Scholar
  43. 43.
    Murray KJ, Szer W, Grom AA, Donnelly P, Levinson JE (1997) Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene. J Rheumatol 24:560Google Scholar
  44. 44.
    Pereira-Neves L, Palma-Carlos ML, Soares I, Pereira Santos MC, Ganhao F, Palma-Carlos AG (1996) Soluble ICAM-1 and VCAM-1 serum levels in uveitis. Allerg Immunol 28:302Google Scholar
  45. 45.
    Planck SR, Huang X-N, Robertson JE, Rosenbaum JT (1994) Cytokine mRNA levels in rat ocular tissues following systemic endotoxin treatment. Invest Ophthalmol Vis Sci 35:924Google Scholar
  46. 46.
    Rosenbaum JT (1989) Uveitis. An internist's view. Arch Intern Med 149:1173Google Scholar
  47. 47.
    Rosenbaum JT (1989) Characterization of uveitis associated with spondyloarthritis. J Rheumatol 16:792Google Scholar
  48. 48.
    Rosenbaum JT, Samples JR, Hefeneider SH, Howes EL Jr (1987) Ocular inflammatory effects of intravitreal interleukin-1. Arch Ophthalmol 105:1117Google Scholar
  49. 49.
    Rosenbaum JT, Howes EL Jr, Rubin RM, Samples JR (1988) Ocular inflammatory effects of intravitreally injected tumor necrosis factor. Am J Pathol 133:47Google Scholar
  50. 50.
    Rosenbaum JT, Rosenbaum SO, Waldman ML, Angell EM, Torrance DS, Otten-Evans C, Hanna R, Mohler K (1994) Failure to inhibit endotoxin-induced uveitis with soluble TNF receptors. Reg Immunol 6:73Google Scholar
  51. 51.
    Rosenbaum JT, Han YB, Park JM, Kennedy M, Planck SR (1998) Tumor necrosis factor-α is not essential in endotoxin induced eye inflammation: Studies in cytokine receptor deficient mice. J Rheumatol 25:2408–2416Google Scholar
  52. 52.
    osenbaumJT, Kievit P, Han YB, Park JM, Planck SR (1998) Interleukin-6 does not mediate endotoxin-induced uveitis in mice: studies in gene deletion animals. Invest Ophthalmol Vis Sci 39:64Google Scholar
  53. 53.
    Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR (1980) Endotoxin-induced uveitis in rats as a model for human disease. Nature 286:611Google Scholar
  54. 54.
    Rosenbaum JT, Hendricks PA, Shively JE, McDougall IR (1983) Distribution of radiolabelled endotoxin with particular reference to the eye: concise communication. J Nucl Med 11:383Google Scholar
  55. 55.
    Rosenbaum JT, Angell E (1995) Paradoxical effects of IL-10 in endotoxin-induced uveitis J Immunol 155:4090Google Scholar
  56. 56.
    Rosenbaum JT, Boney RS (1992) Activity of an interleukin-1 receptor antagonist in rabbit models of uveitis. Arch Ophthalmol 110:547Google Scholar
  57. 57.
    Rosenbaum JT, Boney RS (1993) Efficacy of antibodies to adhesion molecules, CD11a or CD18, in rabbit models of uveitis. Curr Eye Res 12:827Google Scholar
  58. 58.
    Rosenbaum JT, Howes EL Jr, English D (1985) Ascorbate in aqueous humor protects against myeloperoxidase-induced oxidation. Am J Pathol 120:244Google Scholar
  59. 59.
    Rosenbaum JT, Nozik RA (1985) Uveitis: many diseases, one diagnosis. Am J Med 79:545Google Scholar
  60. 60.
    Rothova A, Buntenhuis HJ, Christiaans BJ, Linssen A, Vandergaag R, Kijlstra A, Feltkamp TEW (1983) Acute anterior uveitis (AAU) and HLA-B27. Br J Rheumatol 22:144Google Scholar
  61. 61.
    Rubin RM, Samples JR, Rosenbaum JT (1988) Prostaglandin-indepedent inhibition of ocular vascular permeability by a platelet-activating factor antagonist. Arch Ophthalmol 106:1116Google Scholar
  62. 62.
    Samples JR, Boney RS, Tilden M, Rosenbaum JT (1990) Granulocyte-macrophage colony stimulating factor lowers intraocular pressure with intravitreal injection [Abstract]. Invest Ophthalmol Vis Sci 31:228Google Scholar
  63. 63.
    Samples JR, Boney RS, Rosenbaum JT (1993) Ocular inflammatory effects of intravitreally injected interleukin-2. Curt Eye Res 12:649Google Scholar
  64. 64.
    Scofield RH, Warren WL, Koelsch G, Harley JB (1993) A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution. Proc Natl Acad Sci USA 90:9330Google Scholar
  65. 65.
    Semel J, Bowe B, Guo A, Lee L, Rife L, Polikoff D, Summanen P, Pararajasegaram G, Finegold SM, Rao N, Smith RE (1992)Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat. Invest Ophthalmol Vis Sci 33:1766Google Scholar
  66. 66.
    Singh VK, Yamaki K, Donoso LA, Shinohara T (1989) Molecular mimicry. Yeast histone H3-induced experimental autoimmune uveitis. J Immunol 142:1512Google Scholar
  67. 67.
    Streilein JW, Wilbanks GA, Cousins SW (1992) Immunoregulatory mechanisms of the eye. J Neuroimmunol 39:185Google Scholar
  68. 68.
    Suzuma K, Mandai M, Kogishi J, Tojo SJ, Honda Y, Yoshimura N (1997) Role of P-selectin in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 38:1610Google Scholar
  69. 69.
    Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, Balish E, Hammer RE (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 180:2359Google Scholar
  70. 70.
    Vadot E, Barth E, Billet P (1994) Epidemiology of uveitis - Preliminary results of a prospective study in Savoy. In: Saari KM (ed) Uveitis update. Excerpta Medica, New YorkGoogle Scholar
  71. 71.
    Verhagen C, Mor F, Cohen IR (1994) T cell immunity to myelin basic protein induces anterior uveitis in Lewis rats. J Neuroimmunol 53:65Google Scholar
  72. 72.
    Wang H-M, Gabrielian K, Ogden TE, Rayn SJ (1992) Effects of activated macrophages and their secreted products on experimental traction retinal detachment (TRD) [Abstract]. Invest Ophthalmol Vis Sci 33:856Google Scholar
  73. 73.
    Whitcup SM, Chan C-C, Li Q, Nussenblatt RB (1992) Expression of cell adhesion molecules in posterior uveitis. Arch Ophthalmol 110:662Google Scholar
  74. 74.
    Whitcup SM, DeBarge LR, Rosen H, Nussenblatt RB, Chan C-C (1993) Monoclonal antibody against CD11b/Cd18 inhibits endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 34:673Google Scholar
  75. 75.
    Whitcup SM, Hikita N, Shirao M, Miyasaka M, Tamatani T, Mochizuki M, Nussenblatt RB, Chan C-C (1995) Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis. Exp Eye Res 60:597Google Scholar
  76. 76.
    Whitcup SM, Kozhich AT, Lobanoff M, Wolitsky BA, Chan C-C (1997) Blocking both E-selectin and P-selectin inhibits endotoxin-induced leukocyte infiltration into the eye. Clin Immunol Immunopathol 83:45Google Scholar
  77. 77.
    Whitcup SM, Rizzo LV, Lai JC, Hayashi S, Gazzinelli R, Chan CC (1996) IL-l2 inhibits endotoxin-induced inflammation in the eye. Eur J Immunol 26:995Google Scholar
  78. 78.
    Wildner G, Thurau SR (1994) Cross-reactivity between an HLA-B27-derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex association with autoimmune disease. Eur J Immunol 24:2579Google Scholar
  79. 79.
    79.Winterbauer RH, Belie N, Moores KD (1973) A clinical interpretation of bilateral hilar adenopathy. Ann Intern Med 78:65Google Scholar
  80. 80.
    Zaman AG, Edelsten C, Stanford MR, Graham EM, Ellis BA, Direskeneli H, D'Cruz DP, Hughes GRV, Dumonde DC, Wallace GR (1994) Soluble intercellular adhesion molecule-1 (sICAM-1) as a marker of disease relapse in idiopathic uveoretinitis. Clin Exp Immunol 95:60Google Scholar
  81. 81.
    Zhang J-J, Hamachi M, Hamachi T, Zhao Y-P, Yu DTY (1989) The bacterial outer membrane protein that reacts with anti-HLA-B27 antibodies is the OMPA protein. J Immunol 143:2955Google Scholar

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • James T. Rosenbaum
    • 1
  • Tammy M. Martin
    • 1
  • Stephen R. Planck
    • 1
  1. 1.Oregon Health Sciences University, Casey Eye InstitutePortlandUSA

Personalised recommendations