Skip to main content
SpringerLink
Log in

Acetylenic chemistry, part XXVI: One-pot synthesis of 1,3-dialkylated derivatives of quinazolinone and its aza-analogue via mitsunobu reaction

Acetylenchemie, 26. Mitt.: Ein-Topf-Synthese von 1,3-dialkylierten Derivaten des Chinazolinons und seines Aza-Analogons mittels Mitsunobu-Reaktion (Kurze Mitt.)

Short communication

  • Organische Chemie Und Biochemie
  • Published:
Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary

Quinaozolin-2,4-(1H,3H)-dione (1), 6,7-dimethoxy-quinazolin-2,4-(1H,3H)-dione (2), and 1,2,3,4-tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidine (3) were subjected to Mitsunobu conditions using propinol to give the 1,3-dialkylated derivatives4,5, and6.

Zusammenfassung

Chinazolin-2,4-(1H,3H)-dion (1), 6,7-Dimethoxychinazolin-2,4-(1H,3H)-dion (2) und 1,2,3,4-Tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidin (3) werden unter Mitsunobu-Bedingungen mit Propinol umgesetzt und ergeben die 1,3-dialkylierten Derivate4,5 und6.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Acetylenic Chemistry, XXV: Reisch J., Iding M., Schönweiler D. (in press) J. Heterocycl. Chem.

  2. Reisch J., Usifoh C. O., Oluwadiya J. O. (1992) Monatsh. Chem.123: 247

    Google Scholar 

  3. Reisch J., Usifoh C. O., Oluwadiya J. O. (1990) J. Heterocycl. Chem.27: 1953

    Google Scholar 

  4. Reisch J., Usifoh C. O., Okoh E., Oluwadiya J. O., (1992) Pharmazie47: 18

    Google Scholar 

  5. Amiss A. M., Mehta D. R., Samarth S. S. (1970) Prog. Drug Res.14: 218

    Google Scholar 

  6. Akgiin H., Hollstein U., Hurwitz L. (1988) J. Pharm. Sci.77: 735

    Google Scholar 

  7. Johne S. (1982) Prog. Drug Res.26: 259

    Google Scholar 

  8. Vida J. A. (1977) Anticonvulsants. Academic Press, New York, pp. 428, 432–450, 471–472

    Google Scholar 

  9. Sent to National Cancer Institute (NCI), Bethesda, Maryland, USA, for anti-cancer screening

  10. Danielsson B., Skoglund E. (1965) Acta Pharm. Suec.2: 167

    Google Scholar 

  11. Reisch J., Usifoh C. O., Oluwadiya J. O. (1990) J. Heterocycl. Chem.27: 287

    Google Scholar 

  12. Mitsunobu O. (1981) Synthesis: 1

Download references

Author information

Author notes

  1. Akkinepalli Raghu Ram Rao

    Present address: University College of Pharmaceutical Sciences, Kakatiya University, 506 009, Warangal, A.P., India

Authors and Affiliations

  1. Institut für Pharmazeutische Chemie, Westfälische Wilhelms-Universität, D-48149, Münster, Federal Republic of Germany

    Johannes Reisch & Akkinepalli Raghu Ram Rao

  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

    Cyril O. Usifoh

Authors
  1. Johannes Reisch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akkinepalli Raghu Ram Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cyril O. Usifoh
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reisch, J., Rao, A.R.R. & Usifoh, C.O. Acetylenic chemistry, part XXVI: One-pot synthesis of 1,3-dialkylated derivatives of quinazolinone and its aza-analogue via mitsunobu reaction. Monatsh Chem 124, 1217–1220 (1993). https://doi.org/10.1007/BF00810032

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00810032

Keywords

Search

Navigation