Skip to main content
Log in

Hyperplastic processes in mitochondria of heart-muscle cells after administration of toxic doses of adrenalin

  • Morphology and Pathomorphology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Hyperplastic processes in mitochondria of heart-muscle cells of albino rats during administration of toxic doses of adrenalin were studied experimentally. Electron-microscopic investigation revealed three types of mitochondria. Those of the first type had dimensions and structure characteristic of myocardial muscle cells. Those of the second type had an extremely dense, finely granular matrix and many cristae per unit area. Mitochondria of the third type had two “compartments” differing in the density of their matrix and the arrangement and number of their cristae under a common outer membrane. It is postulated that the ultrastructural differences between the mitochondria of these three types reflect their functional state.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literature Cited

  1. T. P. Beketova, in: Proceedings of the 9th All-Union Conference on Electron Microscopy [in Russian], Moscow (1973), p. 385.

  2. N. N. Beskrovnova, “Changes in myocardial ultrastructure under the influence of mediators of the autonomic nervous system and cardiac glycosides”, Author's Abstract of Candidate's Dissertation, Moscow (1972).

  3. M. M. Gachava, “The effect of structural components of the mitochondria on template activity of mitochondrial DNA”, Author's Abstract of Candidate's Dissertation, Leningrad (1971).

  4. K. M. Danilova, Arkh. Pat., No. 11, 11 (1961).

    Google Scholar 

  5. L. A. Kopteva and V. I. Biryuzova, Byull. Éksperim. Biol. i Med., No. 7, 19 (1968).

    Google Scholar 

  6. M. I. Klibaner, “Adrenalin necrosis and repair of the myocardium”, Candidate's Dissertation, Moscow (1973).

  7. V. L. Kozel'tsev and Yu. A. Khoroshkov, in: Proceedings of the 9th All-Union Conference on Electron Microscopy [in Russian], Moscow (1973), p. 391.

  8. E. V. Kozyreva and V. M. Mityushin, in: Mitochondria. Structure and Functions in Health and Disease [in Russian], Moscow (1971), p. 113.

  9. K. S. Mitin and T. P. Beketova, Byull. Éksperim. Biol. i Med., No. 2, 117 (1972).

    Google Scholar 

  10. K. S. Mitin, M. M. Beskrovnova, et al., Byull. Éksperim. Biol. i Med., No. 6, 103 (1971).

    Google Scholar 

  11. D. S. Sarkisov, Regeneration and Its Clinical Importance [in Russian], Moscow (1970), p. 23.

  12. V. P. Skulachev, The Transformation of Energy in Biomembranes [in Russian], Moscow (1972), p. 157.

  13. Yu. G. Tsellarius and L. A. Semenova, Histopathology of Focal Metabolic Lesions of the Myocardium [in Russian], Novosibirsk (1972).

  14. H. David, A. Hecht, and J. Verlings, Beitr. path. Anat.,137, 1 (1968).

    Google Scholar 

  15. C. R. Hackenbrock, J. Cell. Biol.,30, 269 (1966).

    Google Scholar 

  16. C. R. Hackenbrock, J. Cell. Biol.,37, 34 (1968).

    Google Scholar 

  17. S. S. Nachbaur and P. M. Vignais, Biochem. Biophys. Res. Commun.,33, 315 (1968).

    Google Scholar 

  18. C. R. Rossi, L. Sartorelli, L. Tato, et al., Biochim. Biophys. Acta,98, 207 (1965).

    Google Scholar 

  19. S. Wenzel, S. Verlings, and A. Hecht, Exp. Path. (Jena),3, 327 (1969).

    Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mitin, K.S., Kleimenova, N.N. Hyperplastic processes in mitochondria of heart-muscle cells after administration of toxic doses of adrenalin. Bull Exp Biol Med 80, 822–825 (1975). https://doi.org/10.1007/BF00809903

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00809903

Key Words

Navigation