Abstract
To reproduce the local Schwartzmann phenomenon, heat-killed cells ofCitrobacter orEscherichia coli were injected intradermally and intravenously into 11 germfree guinea pigs, two guinea pigs monoassociated withCitrobacter, and 25 control guinea pigs. All the germfree animals were refractory to the phenomenon, whereas 20 of the 25 control animals gave a positive reaction. A zone of infiltration at the site of intradermal injection was present in all the control guinea pigs but in none of the germfree animals. The possible primary and secondary mechanisms of suppression of the Schwartzmann phenomenon in the absence of the normal microflora are discussed.
Similar content being viewed by others
Literature Cited
I. A. Oivin and V. M. Volodin “The Schwartzmann phenomenon and its role in pathology,” Pat. Fiziol., No. 4, 14 (1965).
O. V. Chakhava, Gnotobiology [in Russian], Meditsina, Moscow (1972).
O. V. Chakhava, “Ascorbic acid and glucocorticoid levels in relation to underdeveloped lymphatic tissue in germfree guinea pigs,” in: Germfree Research, J. B. Heneghan (Editor), New York (1973), pp. 507–511.
W. R. Bliss and J. A. Sibley, “The Schwartzmann phenomenon and acute hemorrhagic pancreatitis. A study in dogs,” Am. J. Surg.,117, 711 (1969).
W. Boyd, Fundamentals of Immunology, Wiley (1967).
A. J. Braude and H. Douglas, “Passive immunization against the local Schwartzmann reaction,” J. Immunol.,108, 505 (1972).
J. R. Frey, A. C. de Weck, and H. Geleick, “Immunologic specificity of the localized Schwartzmann phenomenon elicited in guinea pigs hypersensitive to simple chemical haptens,” in: Immunopathology (International Symposium), P. A. Miescher and P. Grabar (Editors), New York (1967), p. 313.
S. B. Jensen, S. B. Mergenhagen, R. J. Fitzgerald, et al., “Susceptibility of conventional and germfree mice to lethal effects of endotoxin,” Proc. Soc. Exp. Biol. (New York),113, 710 (1963).
M. Lev and J. R. Battisto, “Impaired delayed hypersensitivity in germ-free guinea pigs,” Immunology,19, 47 (1970).
L. Mandel and J. Travnicek, “The development of some blood coagulation factors in germfree and monocontaminated baby pigs,” in: Advances in Germfree Research and Gnotobiology, M. Miyakawa and T. D. Luckey (Editors), (International Symposium), Cleveland (1968), p. 89.
L. Polak and J. L. Turk “Suppression of the haemorrhagic component of the Schwartzmann reaction by anti-complement serum,” Nature,223, 738 (1969).
G. Schwartzmann, Phenomenon of Local Tissue Reactivity, London (1937).
G. Tibor, D. Kovacs, et al., “Local increased sensitivity to endotoxin and its relationship to the Schwartzmann phenomenon,” Zh. Mikrobiol., No. 10, 89 (1962).
P. Vegh, I. Takats, and T. G. Kovats, “In vitro neutralization of the Schwartzmann-inducing activity of endotoxins by immune serum,” Immunology,19, 41 (1970).
Rights and permissions
About this article
Cite this article
Chakhava, O.V., Pershin, B.B. & Shustrova, N.M. Local Schwartzmann's phenomenon in germfree guinea pigs. Bull Exp Biol Med 80, 799–801 (1975). https://doi.org/10.1007/BF00809895
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00809895