Radioprotective effect of some pyrazolone derivatives

  • A. V. Piskarev
  • V. S. Nesterenko
Pharmacology
  • 32 Downloads

Abstract

Analgin, antipyrine, and aminopyrine, if administered to mice in large doses 3 h before irradiation (800 R), increased the survival rate and prolonged the life of the dying animals. In combination with cystamine, these compounds increased the changes of survival of the mice after the period of acute intestinal death following irradiation in a dose of 1050 R. In therapeutic doses the pyrazolone derivatives had a less marked radioprotective effect.

Key Words

pyrazolone derivatives acute radiation sickness 

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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • A. V. Piskarev
  • V. S. Nesterenko

There are no affiliations available

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