Mechanism of hypoprothrombinemia and hypoproconvertinemia in experimental thyrotoxicosis

  • N. N. Petrishchev
  • V. I. Kiyanov
Pathological Physiology and General Pathology


Indices of the thromboelastogram (TEG) and the activity and breakdown of prothrombin and proconvertin in experimental thyrotoxicosis were studied in experiments on rats. In the presence of marked thyrotoxicosis most of the indices of the TEG shifted toward hypocoagulation: thrombin formation was slowed, the total coagulation constant was increased, and maximal amplitude was reduced. A decrease in the activity and intensified breakdown of prothrombin and, in particular, of proconvertin also were observed. It is postulated that increased destruction of these factors plays a fundamental role in the pathogenesis of the hypoprothrombinemia and hypoproconvertinemia accompanying thyrotoxicosis.

Key Words

prothrombin proconvertin thyrotoxicosis 

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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • N. N. Petrishchev
  • V. I. Kiyanov

There are no affiliations available

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