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Oxadiazole condensed ring systems, I: Synthesis of 1,3,4-oxadiazolo[3,2-a]pyrimidin-5-ones as possible antimicrobial agents

Kondensierte Ringsysteme des Oxadiazols, 1. Mitt.: Synthese von 1,3,4-Oxadiazolo[3,2-a]pyrimidin-5-onen als potentiell antimikrobielle Substanzen

  • Organische Chemie Und Biochemie
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Summary

Syntheses of some substituted 7-hydroxy-5H-1,3,4-oxadiazolo[3,2-a]pyrimidin-5-ones (3) and their 7-methoxy (4), 7-chloro (5) and 7-azido (6) derivatives are described. 2-Phenyl-N,N′-bis(3-tolyl)propanediamide (8) was obtained, instead of the expected triazolopyrimidinone7 upon reacting3b withm-toluidine. Three compounds were screened forin vitro antibacterial and antifungal activities.

Zusammenfassung

Die Synthese einiger substituierter 7-Hydroxy-5H-1,3,4-oxadiazolo[3,2-a]-pyrimidin-5-one (3) und ihrer 7-methoxy (4), 7-chloro (5) und 7-azido (6) Derivate wird beschrieben. Anstelle des erwarteten Triazolo-pyrimidinons7 entsteht bei der Reaktion von3b mitm-Toluidin 2-Phenyl-N,N′-bis(3-tolyl)-propandiamid (8). Drei Verbindungen wurden auf antimikrobakterielle und fungizide Wirkung geprüft.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, 21521, Alexandria, Egypt

    El-Sayed A. M. Badawey, Ahmed M. M. Hassan & Farid S. G. Soliman

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  1. El-Sayed A. M. Badawey
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  2. Ahmed M. M. Hassan
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  3. Farid S. G. Soliman
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Badawey, ES.A.M., Hassan, A.M.M. & Soliman, F.S.G. Oxadiazole condensed ring systems, I: Synthesis of 1,3,4-oxadiazolo[3,2-a]pyrimidin-5-ones as possible antimicrobial agents. Monatsh Chem 121, 665–669 (1990). https://doi.org/10.1007/BF00809770

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  • DOI: https://doi.org/10.1007/BF00809770

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