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Monatshefte für Chemie / Chemical Monthly

, Volume 119, Issue 10, pp 1091–1101 | Cite as

Metal complexes of the diuretic drug furosemide

  • Vaggelis Hondrellis
  • Themistoclis Kabanos
  • Spyros P. Perlepes
  • John M. Tsangaris
Anorganische Und Physikalische Chemie

Abstract

New complexes of the formulaeM(fur)2·2H2O (M = Mn, Cu, Zn),M(fur)2·3H2O (M = Co, Ni, Cd), Hg2(fur)3Cl2·2H2O, Pd(fur)Cl·H2O and Rh(fur)3·3H2O, wherefurH = 4-chloro-N-(2-furfuryl)-5-sulfamoylanthranilic acid, have been prepared and characterized by conductivity measurements, X-ray powder patterns, thermal methods, effective magnetic moments as well as by IR, ligand field,1H-NMR and ESR spectroscopic studies. The anionfur shows a chelated bidentate O(carboxylato), N(imino)-coordinating behaviour.

Keywords

Furosemide Metal-sulfadrug interactions Ligand field spectra IR 1H-NMR Magnetic moments 

Metallkomplexe der diuretischen Droge Furosemid

Zusammenfassung

Neue Komplexe der Verbindungen:M(fur)2·2H2O (M = Mn, Cu, Zn),M(fur)2·3H2O (M = Co, Ni, Cd), Hg2(fur)3Cl2·2H2O, Pd(fur)Cl·H2O und Rh(fur)3·3H2O, wobeifurH 4-chlor-N-(2-furfuryl)-5-sulfamoylanthanilsäure ist, wurden dargestellt. Die Komplexe wurden durch Leitfähigkeitsmessungen, Röntgen-Pulver-Aufnahmen, thermogravimetrische Analysen, Messungen des effektiven magnetischen Dipolemomentes sowie durch spektroskopische Untersuchungen (IR,1H-NMR und ESR) charakterisiert. Das Anionfur zeigt das Verhalten einer Chelat-bidentat-O(carboxylato),N(imino)-Koordination.

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Vaggelis Hondrellis
    • 1
  • Themistoclis Kabanos
    • 1
  • Spyros P. Perlepes
    • 1
  • John M. Tsangaris
    • 1
  1. 1.Laboratory of Inorganic Chemistry, Chemistry DepartmentUniversity of IoanninaIoanninaGreece

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