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On theMichael type addition of dipeptides to 4-oxo-4-phenyl-2-butenoic acid derivatives

ZurMichael-ähnlichen Addition von Dipeptiden an Derivate der 4-Oxo-4-phenyl-2-butensäure (Kurze Mitteilung)

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  • Organische Chemie Und Biochemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Abstract

The title reaction afforded the adducts3 in variable selectivity, but the isomers of (S,S,S)-configuration were easily isolated; the reversibility of the reaction permits the recovery of the starting materials from the mother liquor. High selectivity has been observed in one case only.

Zusammenfassung

Die Titelreaktion liefert die Addukte3 in unterschiedlicher Selektivität; die Isomeren mit (S,S,S)-Konfiguration konnten jedoch einfach isoliert werden, und die Reversibilität der Reaktion ermöglicht die Rückgewinnung der Ausgangsstoffe. Eine hohe Selektivität wurde nur in einem Fall beobachtet.

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References

  1. Preston J,Carling WR (1982) Eur P 84941

  2. Greenlee WJ (1984) US 4 442 030

  3. Fodor T,Dobay L,Fischer J,Stefkó B (1986) Eur P 192393

  4. Wu MT, Douglas AW, Ondeyka DL, Payne LG, Ikeler TJ, Joshua H, Patchett AA (1985) J Pharm Chem 74: 352

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Authors and Affiliations

  1. Gedeon Richter Pharmaceutical Works Ltd., c/o MTA KKI, H-1025, Budapest, Hungary

    János Fischer, Tamás Fodor & László Dobay

Authors
  1. János Fischer
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  2. Tamás Fodor
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  3. László Dobay
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Fischer, J., Fodor, T. & Dobay, L. On theMichael type addition of dipeptides to 4-oxo-4-phenyl-2-butenoic acid derivatives. Monatsh Chem 119, 645–647 (1988). https://doi.org/10.1007/BF00809215

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  • DOI: https://doi.org/10.1007/BF00809215

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