Cytotoxic and blocking antibodies in serum and spleen cell eluates of mice with Rauscher leukemia depending on its course
- 14 Downloads
Functional antagonism of cytotoxic and blocking humoral antibodies belonging to the same class of IgG and directed against type-specific antigen of Rauscher virus was found. Progression of leukemia in C57BL/6 and BALB/c mice inoculated with Rauscher virus and Freund's complete adjuvant was shown to be coupled with the production of 7S immunoglobulin (IgG) antibodies blocking in vitro the cytotoxic effect of 19S antibodies against the group-specific surface antigen of mouse leukemias, and later blocking also 7S antibodies against type-specific antigen. Regression of leukemia in C57BL/6 mice is connected with the cessation of production of both types of blocking antibodies. Complete resistance of C57BL/6 mice to the leukemogenic action of Rauscher virus is brought about immunologically by the production of cytotoxic humoral antibodies against type-specific antigen in the total absence of production of blocking antibodies.
Key WordsRauscher virus mouse leukemia antitumor antibodies
Unable to display preview. Download preview PDF.
- 1.V. S. Ter-Grigorov, R. Ya. Moskovkina, F. Todt, et al., Vopr. Onkol., No. 4, 70 (1971).Google Scholar
- 2.V. S. Ter-Grigorov, B. I. Shevelev, O. Ya. Moskovkina, et al., Byull. Eksperim. Biol. i Med., No. 1, 61 (1971).Google Scholar
- 3.J. Hellström and K. E. Hellström, Intern. J. Cancer,5, 195 (1970).Google Scholar