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Zur Kenntnis der Reaktionsfähigkeit des 5-Methyl-4-ethyl-2-propanonyl-thiazols

On the reactivity of 5-methyl-4-ethyl-2-propanonyl-thiazol. Joint reaction of elementary sulfur and gaseous ammonia with ketones, 97

Über die gemeinsame Einwirkung von elementarem Schwefel und gasförmigem Ammoniak auf Ketone, 97. Mitt.

  • Organische Chemie Und Biochemie
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Abstract

The methylene group of 5-methyl-4-ethyl-2-propanonyl-thiazol (II) reacts with different aldehydes yielding theKnoevenagel-condensation products (1–14). The reactions ofII with amines or ammonia gives exclusively the enamines as demonstrated by the1H-NMR-spectrum (15–23). The reaction product fromII with ammonia (23) can be further transformed to the corresponding derivatives of urea (24–27) with isocyanates.II reacts with acylchlorides in pyridine to the 0-acylation compounds (28–32) and with isocyanates to the corresponding urethanes (38–40).

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Authors and Affiliations

  1. Institut für Technische Chemie und Petrolchemie, Rheinisch-Westfälische Technische Hochschule Aachen, D-5100, Aachen, Bundesrepublik Deutschland

    Friedrich Asinger, Joachim Wadehn & Karina Giesbertz

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  1. Friedrich Asinger
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  2. Joachim Wadehn
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  3. Karina Giesbertz
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Asinger, F., Wadehn, J. & Giesbertz, K. Zur Kenntnis der Reaktionsfähigkeit des 5-Methyl-4-ethyl-2-propanonyl-thiazols. Monatsh Chem 113, 1311–1319 (1982). https://doi.org/10.1007/BF00808746

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  • DOI: https://doi.org/10.1007/BF00808746

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