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Effect of rhythm of pathogenic action on cell response of the liver stroma

  • Morphology and Pathomorphology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The speed of the cell response of the mouse liver stroma, its stereotype, and its cyclic pattern were found to depend on the rhythm of action and the total dose of CCl4 used as a hepatotropic poison. The rhythm of the stromal response showed quantitative changes in the infiltrating cells. During the action of CCl4 on the liver morphological evidence of humoral (fixation of γ-globulin and of complement-reactive groups) and cellular (infiltration with macrophages and lymphocytes, signs of cellular aggression in the form of “piecemeal” necrosis) immunity were observed in the liver. With a more intensive rhythm of CCl4 administration the adaptive responses of the stroma and parenchyma were more marked, and this resulted in more complete regeneration.

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Authors
  1. I. V. Popova
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Popova, I.V. Effect of rhythm of pathogenic action on cell response of the liver stroma. Bull Exp Biol Med 78, 1441–1443 (1974). https://doi.org/10.1007/BF00808729

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  • DOI: https://doi.org/10.1007/BF00808729

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