Abstract
Examination of workers in contact with dyes containing radicals of carcinogenic compounds revealed disturbances of the mucous membrane of the urinary bladder (papillary changes, chronic cystitis, trigonitis). Immunoserologic investigation of the blood serum of these workers by means of an immunologic method suggested for the diagnosis of carcinoma of the urinary bladder revealed 3-hydroxyanthranilic acid, a tryptophan metabolite, in the blood of some of the workers as a hapten. The frequency of discovery of this metabolite, like the frequency of detection of pathological changes in the mucous membrane of the urinary bladder, depended on the degree of contact of the workers with the dyes. It is concluded that the immunologic determination of 3-hydroxyanthranilic acid can be used for the detection of persons with a risk of developing occupational bladder tumors.
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Literature Cited
A. T. Zasypka, Vopr. Onkol., No. 7, 108 (1969).
T. A. Korosteleva, Changes in Tissue Antigens during Experimental Carcinogenesis [in Russian], Leningrad (1966).
T. A. Korosteleva and A. T. Zasypka, Vopr. Onkol., No. 9, 53 (1968).
T. A. Korosteleva and A. T. Zasypka, Vopr. Onkol., No. 10, 47 (1970).
T. A. Korosteleva, B. V. Klyucharev, and A. T. Belokhvostova, Vopr. Onkol., No. 3, 59 (1971).
T. A. Korosteleva, E. N. Krutova, and A. T. Zasypka, Vopr. Onkol., No. 2, 44 (1966).
J. M. Price, Canadian Cancer Conference (Proceedings), Vol. 6, New York (1966), p. 224.
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Korosteleva, T.A., Klyucharev, B.V., Belokhvostova, A.T. et al. Immunodiagnosis of precancerous changes in the mucous membrane of the urinary bladder by determination of the serum 3-hydroxyanthranilic acid. Bull Exp Biol Med 78, 1405–1407 (1974). https://doi.org/10.1007/BF00808718
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DOI: https://doi.org/10.1007/BF00808718