Abstract
Preparation of purified actomyosin-like protein (ALP) was isolated from the coarse fraction of rat brain mitochondria. The ALP preparation contained Mg(Ca)-ATPase activity, inhibited by 0.1% deoxycholate, together with acetylcholinesterase activity and contractility (superprecipitation reaction). The contraction of ALP and ATPase activity were considerably reduced by tetanus toxin. Inactivated toxin had no effect. The possible functional role of ALP in the maintenance and secretion of mediators by nerve endings is discussed.
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Laboratory of General Pathology of the Nervous System, Institute of Normal and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 78, No. 12, pp. 24–27, December, 1974.
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Kryzhanovskii, G.N., Glebov, R.N., Dmitrieva, N.M. et al. Effect of tetanus toxin on contractility of the actomyosin-like protein of rat brain. Bull Exp Biol Med 78, 1365–1368 (1974). https://doi.org/10.1007/BF00808706
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DOI: https://doi.org/10.1007/BF00808706