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An increased number of hematopoietic stem cells in mice in the initial period of the stress reaction

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A nonspecific response of the bone marrow, consisting of an increase in the number of lymphocytes and a decrease in the number of mature granulocytes, takes place in F1(CBA×C57BL) mice in a state of stress. In the bone marrow 9–12 h after the beginning of the stress reaction to immobilization for 3 h the number of cells capable of forming colonies in the spleen when transplanted into lethally irradiated recipients is increased by 45–50%. This increase is interpreted as the result of division of stem cells as a result of a stress-induced change in the microstructure of the bone marrow.

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Authors
  1. Yu. I. Zimin
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Zimin, Y.I. An increased number of hematopoietic stem cells in mice in the initial period of the stress reaction. Bull Exp Biol Med 78, 1358–1360 (1974). https://doi.org/10.1007/BF00808703

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  • DOI: https://doi.org/10.1007/BF00808703

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