Amino Acids

, Volume 6, Issue 1, pp 65–96 | Cite as

Studies on advanced glycation end products by recent mass spectrometric techniques

  • A. Lapolla
  • D. Fedele
  • P. Traldi


The results obtained by different mass spectrometric approaches in the field of advanced glycation of proteins are reported and discussed in detail in comparison with those obtained by other analytical methodologies (fluorescence and absorbance spectroscopies, radioimmunoassay, enzyme-linked immunosorbent assay). They have been subdivided in three main groups: analysis on degraded glycated proteins, direct analysis of glycated proteins and studies on the reaction between protected lysine and glucose. The general overview so achieved indicate mass spectrometry as a particularly valid analytical method in this field of research.


Amino acids Diabetes Non enzymatic glycation Advanced glycation end products (AGE) Mass spectrometry HPLC Laser desorption 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • A. Lapolla
    • 1
  • D. Fedele
    • 1
  • P. Traldi
    • 2
  1. 1.Istituto di Medicina Interna - Patologia MedicaPadovaItaly
  2. 2.CNR Area di RicercaPadovaItaly

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