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Amino Acids

, Volume 11, Issue 3–4, pp 397–408 | Cite as

Stereoselective synthesis ofβ-amino acids via conjugate addition of nitrogen nucleophiles toα,β-unsaturated esters — Recent advances

  • N. Sewald
Review Article

Summary

The latest results concerning the asymmetric synthesis ofβ-amino acids are reviewed, focussing on methodology involving 1,4-addition of nitrogen nucleophiles toα,β-unsaturated esters. Approaches using both homochiral auxiliaries bound to the enoate and homochiral ammonia equivalents are included as well as alkylations and aldol reactions of enolates derived from homochiralβ-amino acids.

Keywords

β-Amino acids α-Deuterio-β-amino acids α-Alkyl-β-amino acids α-Hydroxy-β-amino acids Conjugate addition Nitrogen nucleophiles Homochiral ammonia equivalents α,β-Unsaturated esters 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • N. Sewald
    • 1
  1. 1.Institut für Organische Chemie der Universität LeipzigLeipzigGermany

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