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Studies on cyclic dipeptides, I: Aryl modifications ofcyclo-[Phe-His]

Untersuchungen über cyclische Dipeptide, I. Mitt.: Aryl-Modifikationen voncyclo-[Phe-His]

  • Organische Chemie Und Biochemie
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Summary

Seven new cyclic dipeptides have been synthesized and tested for their applicability as tools to elucidate the mechanism of formation of mandelonitrile with (SS)-cyclo-[Phe-His] type catalysts. Conformational analyses based on1H NMR spectra are presented for all prepared cyclic dipeptides.

Zusammenfassung

Es wurden sieben neue cyclische Dipeptide synthetisiert und auf ihre Anwendbarkeit als (SS)-cyclo-[Phe-His]-ähnliche Katalysatoren zur Bildung von Mandelsäurenitril und zur Untersuchung des Mechanismus dieser Reaktion getestet. Konformationsanalysen aller dargestellten cyclischen Dipeptide — basierend auf1H-NMR-Spektren — werden vorgestellt.

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Authors and Affiliations

  1. Institut für Pharmazeutische Chemie, Christian-Doppler-Laboratorium für Chemie Chiraler Verbindungen, Johann-Wolfgang-Goethe-Universität Frankfurt, D-60439, Frankfurt/Main, Germany

    C. R. Noe, A. Weigand & S. Pirker

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  1. C. R. Noe
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  2. A. Weigand
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  3. S. Pirker
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Dedicated to Prof. Dr. Dres. h.c.Herbert Oelschläger on the occasion of his 75th birthday

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Noe, C.R., Weigand, A. & Pirker, S. Studies on cyclic dipeptides, I: Aryl modifications ofcyclo-[Phe-His]. Monatsh Chem 127, 1081–1097 (1996). https://doi.org/10.1007/BF00807581

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  • DOI: https://doi.org/10.1007/BF00807581

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