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Effect of poly-4-vinylpyridine on the number of colony-forming cells in mouse bone marrow and spleen

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Injection of poly-4-vinylpyridine in the maximal tolerated dose into mice doubles the number of colony-forming units (CFU) in the bone marrow and reduces the number of nucleated cells by 22%. The increase in the CFU pool takes place from the second through the seventh day. The number of bone marrow cells starts to decrease 2 h after injection of the polymer and remains below the initial level for 5 days; after the second day, however, it starts to return gradually to normal, which it reaches by the seventh day. The number of CFU in the spleen increases ninefold, and this is accompanied by the development of marked splenomegaly on account of the increase in the number of cells.

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Authors
  1. K. S. Chertkov
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  2. Z. M. Mosina
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  3. A. N. Gvozdetskii
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Chertkov, K.S., Mosina, Z.M. & Gvozdetskii, A.N. Effect of poly-4-vinylpyridine on the number of colony-forming cells in mouse bone marrow and spleen. Bull Exp Biol Med 83, 560–563 (1977). https://doi.org/10.1007/BF00807507

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  • DOI: https://doi.org/10.1007/BF00807507

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