Abstract
Cells forming rosettes with homologous or heterologous spermatozoa were found in the thymus, spleen, and bone marrow of sexually mature guinea pigs and of 14–30-week-old human fetuses, and also in the peripheral blood of men suffering from sterility. On the development of autoimmune orchitis after measured trauma to the testis in rats or after immunization of guinea pigs with testicular tissue homogenate mixed with Freund's complete adjuvant, cells forming rosettes with spermatozoa were found to appear in the spleen and thymus of the rats, and their number in the lymphoid organs of the guinea pigs increased. These procedures had no effect on the number of cells forming rosettes with sheep red blood cells in the lymphoid organs of rats and guinea pigs. The possible use of this newly discovered ability of human and animal lymphocytes to form spontaneous and immune rosettes with spermatozoa as a means of assessing the degree of differentiation of lymphocytes and of their sensitization to spermatozoal antigens in cases of disturbance of spermatogenesis of autoimmune nature is discussed.
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Raitsina, S.S., Chuich, N.A., Khlystova, Z.S. et al. Rosette formation by human, guinea pig, and rat lymphocytes with spermatozoa. Bull Exp Biol Med 83, 548–551 (1977). https://doi.org/10.1007/BF00807503
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DOI: https://doi.org/10.1007/BF00807503