Hormonal treatment of precancerous diseases of the testis in rats
- 12 Downloads
Tumors and foci of proliferation in the testis derived from the spermatogenic epithelium in rats were treated with estrogens, and those derived from interstitial cells of the testis were treated with androgens and with 17-hydroxyprogesterone capronate. In cases of inhibition of the follicle-stimulating function of the pituitary and simultaneous stimulation of the production of luteinizing hormone (LH) growth of teratomas and seminomas was arrested by the action of estrogens and foci of proliferation were absorbed. The depression of LH production by the use of androgens or 17-hydroxyprogesterone capronate was accompanied by cessation of tumor growth and by absorption of foci of proliferation derived from interstitial cells.
Key Wordsgerminogenic tumors follicle-stimulating hormone tumors from interstitial cells luteinizing hormone
Unable to display preview. Download preview PDF.
- 1.V. M. Bresler, Cytological Mechanisms of Carcinogenesis in the Testis [in Russian], Moscow-Leningrad (1964).Google Scholar
- 2.M. G. Goncharova, “The follicle-stimulating function of the pituitary in treatment of mammary gland carcinoma by estrogens,” Author's Abstract of Candidate's Dissertation, Moscow (1970).Google Scholar
- 3.V. N. Dmitriev, Byull. Éksp. Biol. Med., No. 8, 100 (1973).Google Scholar
- 4.E. I. Kotlyarskaya and K. G. Roganova, Akush. Ginekol., No. 1, 18 (1965).Google Scholar
- 5.N. I. Lazarev et al., Mechanisms of the Antitumor Action of Hormones [in Russian], Moscow (1974).Google Scholar
- 6.A. A. Molodyk and M. S. Parkan', Vestn. Akad. Med. Nauk SSSR, No. 3, 94 (1968).Google Scholar
- 7.A. Bahn and R. Bates, J. Clin. Endocrinol.,16, 1337 (1956).Google Scholar
- 8.P. Brown and W. Billewicz, J. Endocrinol.,24, 65 (1962).Google Scholar
- 9.C. Grosvenor and C. Turner, J. Endocrinol.,63, 530 (1958).Google Scholar
- 10.M. R. Rivière, I. Chouroulinkov, M. Guérin, et al., C. R. Acad. Sci. (Paris),249, 2649 (1959).Google Scholar