Abstract
A comparative study was made of the efficacy of various types of deliberate modification of the leukemogenic activity of a transplantable line of bone marrow cells obtained from animals infected with Rauscher leukemia virus. Treatment of the leukemic cells with neuraminidase, or culturing them at a supraoptimal temperature led to complete loss of their leukemogenic activity, as shown by survival of 100% of the experimental animals and the absence of splenomegaly. Meanwhile, treatment of the cells with concanavalin A and 5-bromodeoxyuridine delayed the development of splenomegaly and lowered the mortality among the recipient animals by 70 and 20%, respectively. The results suggest that these methods of action on leukemogenic cells can be used in order to obtain material for subsequent immunization.
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Parfenov, V.V., Tatarinova, Y.N. & Balandin, I.G. Deliberate modification of the specific activity of leukemic cells. Bull Exp Biol Med 83, 527–528 (1977). https://doi.org/10.1007/BF00807496
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DOI: https://doi.org/10.1007/BF00807496