Abstract
A biologically active RNA which, when transferred to chick embryonic cells, produced an antiviral state in them, was isolated from cultures of chick embryonic cells treated with interferon. The level of reproduction of vesicular stomatitis virus in these cells was 2–30% of the level of reproduction observed in cells treated with control RNA. Maximal activity of the experimental RNA was observed after exposure to interferon for 3 h.
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Department of Virology, N. F. Ganaketa Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 4, pp. 436–437, April, 1977.
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Orlova, T.G., Mamontova, T.V., Zhdanova, L.V. et al. Antiviral activity of RNA preparations isolated from interferon-treated cells (messenger RNA or antiviral protein?). Bull Exp Biol Med 83, 509–511 (1977). https://doi.org/10.1007/BF00807491
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DOI: https://doi.org/10.1007/BF00807491