Bulletin of Experimental Biology and Medicine

, Volume 83, Issue 4, pp 507–508 | Cite as

Mechanism of action of aspirin on platelet function

  • V. P. Baluda
  • V. V. Shiryaev
  • N. Simova
  • B. Georgievskaya
Pharmacology
  • 18 Downloads

Abstract

Inhibition of platelet aggregation and of the reaction of liberation of platelet factor 3 under the influence of aspirin was shown to be due to the action of the drug not only on the platelets, but also on plasma cofactors: In experimentsin vitro the blood plasma of rats receiving aspirin reduced the aggregating power of the platelets of intact animals; blood plasma of intact rats increased the aggregating power and accessibility of factor 3 of the platelets of animals receiving aspirin.

Key Words

aspirin platelets blood plasma 

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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • V. P. Baluda
  • V. V. Shiryaev
  • N. Simova
  • B. Georgievskaya

There are no affiliations available

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