Abstract
Changes in the content and incorporation of 5-3H-uridine after brief exposure to its labeled precursor were studied in the individual liver RNA fractions of rats during administration of carbon tetrachloride for 24 weeks. These fractions were obtained by preparative electrophoresis in 2.5% polyacrylamide gel from previously isolated nuclear and cytoplasmic RNA. Administration of CCl4 to rats was shown to reduce the quantity of transfer and ribosomal RNA in the liver tissue. Chronic CCl4 poisoning also disturbs the synchronization of the turnover of the individual components of fast-labeled RNA.
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Literature Cited
L. A. Voronova, S. D. Ivanov, and M. A. Zabezhinskii, Byull. Éksp. Biol. Med.,81, No. 5, 543 (1976).
S. D. Ivanov, Abstracts of Proceedings of a Conference of Junior Scientific Oncologists of Leningrad Research Institute of Oncology [in Russian], Leningrad (1974), p. 36.
S. D. Ivanov, L. A. Voronova, M. A. Zabezhinskii, et al., Vopr. Onkol.,20, No. 8, 54 (1974).
S. D. Ivanov, Yu. P. Zerov, L. A. Voronova, et al., Vopr. Onkol., No. 6, 84 (1974).
N. A. Plokhinskii, Biometrics [in Russian], Moscow (1970).
A. Fisher, The Physiology and Experimental Pathology of the Liver [in Russian], Budapest (1961).
J. Hoffman, M. B. Himes, S. Lapan, et al., Arch. Pathol.59, 429 (1955).
H. J. Seitz and W. Tarnowski, Hoppe-Seylers Z. Physiol. Chem.,349, 1800 (1968).
F. Verney, C. N. Murty, and H. Sidransky, Fed. Proc.,35, 551 (1976).
R. A. Weinberg, Ann. Rev. Biochem.,42, 329 (1973).
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Ivanov, S.D., Voronova, L.A. & Pirozhkov, M.A. Effect of chronic carbon tetrachloride poisoning on the turnover of RNA fractions in rat liver tissue. Bull Exp Biol Med 83, 490–494 (1977). https://doi.org/10.1007/BF00807485
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DOI: https://doi.org/10.1007/BF00807485