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Role of nitrogen metabolism of the brain in the mechanisms of the therapeutic action of hyperbaric oxygen in hemorrhagic shock

  • Biochemistry and Biophysics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Hyperbaric oxygen therapy (3 atm O2, 60 min) of hemorrhagic shock in cats (blood pressure 60/50 mm Hg) prevents the sharp increase, characteristic of hypoxia, in the concentration of ammonia, urea, alanine, and γ-aminobutyric acid in the brain and activates glutamine formation. In the sensomotor cortex the processes of ammonia detoxication via the pathway of increased synthesis of glutamate and glutamine take place more intensively than in the limbic structures of the brain.

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Authors
  1. A. N. Leonov
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  2. V. N. Yakovlev
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Leonov, A.N., Yakovlev, V.N. Role of nitrogen metabolism of the brain in the mechanisms of the therapeutic action of hyperbaric oxygen in hemorrhagic shock. Bull Exp Biol Med 83, 483–486 (1977). https://doi.org/10.1007/BF00807483

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  • DOI: https://doi.org/10.1007/BF00807483

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