Bulletin of Experimental Biology and Medicine

, Volume 83, Issue 4, pp 473–476 | Cite as

Peroxidation of lipids and degeneration of photoreceptors in the retina of rats with avitaminosis E

  • V. E. Kagan
  • G. V. Barybina
  • K. N. Novikov
Pathological Physiology and General Pathology

Abstract

The formation of peroxidation products of lipids (hydroperoxides, dialkyl peroxides, “intermolecular cross linkages”) is sharply intensified in the retina of rats with alimentary avitaminosis Ein vivo and degeneration of the photoreceptors (mainly the layer of outer segments of the rods) develops. The experimental results are discussed on the basis of views regarding the antioxidant mechanism of action of α-tocopherolin vivo.

Key Words

rat retina avitaminosis E peroxidation of lipids degeneration of photoreception layer of the retina 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    L. V. Belousova, L. B. Bratkovskaya, et al., in: Structure, Biosynthesis, and Conversion of Lipidsin vivo [in Russian], Leningrad (1975), p. 28.Google Scholar
  2. 2.
    V. S. Danilov, V. E. Kagan, et al., Izv. Akad. Nauk SSSR, Ser. Biol., No. 4, 584 (1972).Google Scholar
  3. 3.
    V. E. Kagan, A. A. Shvedova, et al., Biofizika No. 6, 1043 (1975).Google Scholar
  4. 4.
    K. N. Novikov, V. E. Kagan, et al., Biofizika, No. 6, 1039 (1975).Google Scholar
  5. 5.
    L. A. Sibel'dina, V. E. Kagan, et al., Dokl. Akad. Nauk SSSR,224, 228 (1975).Google Scholar
  6. 6.
    A. A. Shvedova, “Modification of polyene lipids of the photoreceptors by molecular oxygen and its role in retinal function,” Candidate's Dissertation, Moscow (1975).Google Scholar
  7. 7.
    N. M. Émanuel', E. G. Denisov, and Z. K. Maizus, Chain Reactions of Carbohydrate Oxidation in the Liquid Phase [in Russian], Moscow (1965).Google Scholar
  8. 8.
    R. E. Anderson, et al., Exp. Eye Res.,18, 205 (1974).Google Scholar
  9. 9.
    W. R. Bildlack and A. L. Tappel, Lipids,8, 203 (1973).Google Scholar
  10. 10.
    J. L. Bolland and H. P. Koch, J. Chem. Soc.,7–12, 445, (1945).Google Scholar
  11. 11.
    R. A. Dilley and D. G. McConnell, J. Membr. Biol.,3, 317 (1970).Google Scholar
  12. 12.
    J. Folch, M. Lees, et al., J. Biol. Chem.,191, 883 (1951).Google Scholar
  13. 13.
    M. O. Hall and D. O. Hall, Biochem. Biophys. Res. Commun.,67, 1199 (1975).Google Scholar
  14. 14.
    S. Hayasaka, S. Hara, and S. Mizuno, J. Biochem. (Tokyo),78, 1365 (1975).Google Scholar
  15. 15.
    K. C. Hayes, Invest. Ophthal.,13, 499 (1974).Google Scholar
  16. 16.
    F. G. Jager, Bibl. Nutr. Dieta (Basel),10, 215 (1968).Google Scholar
  17. 17.
    J. Jones and C. Foster, J. Nutr.,24, 245, (1942).Google Scholar
  18. 18.
    V. E. Kagan et al., Biochim. Biophys. Acta,330, 76 (1973).Google Scholar
  19. 19.
    T. Kuwabara and R. A. Gorn, Arch. Ophthal.,77, 115, (1967).Google Scholar
  20. 20.
    R. J. Mullen and M. M. Zavail, Nature,258, 528 (1975).Google Scholar
  21. 21.
    W. K. Noell, in: Biochemistry of the Retina, Academic Press, New York, (1965), pp. 51–72.Google Scholar
  22. 22.
    W. K. Noell, V. S. Walker, et al., Invest. Ophthal.,5, 450 (1966).Google Scholar
  23. 23.
    P. J. O'Brien and R. C. Green, Biochem. J.,103, 32 (1967).Google Scholar
  24. 24.
    M. T. Quaife, N. S. Scrimshaw, and O. H. Lowry, J. Biol. Chem.,180, 1229 (1949).Google Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • V. E. Kagan
  • G. V. Barybina
  • K. N. Novikov

There are no affiliations available

Personalised recommendations