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3-Alkylpyridines III. Total synthesis of both enantiomers of the antineoplastic marine alkaloid niphatesine D

3-Alkylpyridine, 3. Mitt. Totalsynthese von beiden Enantiomeren des antineoplastisch wirksamen marinen Alkaloids Niphatesin D

  • Organische Chemie Und Biochemie
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Summary

A five-step synthesis of both enantiomers of the marine alkaloid niphatesine D (3), starting from the readily available enantiomeric hydroxyalkylthiophenes5 andent-5, is described.

Zusammenfassung

Beide Enantiomere des marinen Pyridinalkaloids Niphatesin D (3) wurden, ausgehend von den gut zugänglichen Hydroxyalkylthiophenen5 undent-5, in jeweils fünf Schritten synthesisiert.

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Authors and Affiliations

  1. Institut für Pharmazeutische Chemie der Technischen Universität Braunschweig, D-38106, Braunschweig, Germany

    F. Bracher & T. Papke

Authors
  1. F. Bracher
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  2. T. Papke
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Additional information

Dedicated to Prof. Dr.E. Reimann on the occasion of his 60th birthday

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Bracher, F., Papke, T. 3-Alkylpyridines III. Total synthesis of both enantiomers of the antineoplastic marine alkaloid niphatesine D. Monatsh Chem 127, 91–95 (1996). https://doi.org/10.1007/BF00807413

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  • DOI: https://doi.org/10.1007/BF00807413

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