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Complex formation between gadolinium(III) porphyrins and some nucleic bases or their nucleoside derivatives in aqueous solutions

Komplexbildung zwischen Gadolinium(III)porphyrinen und einigen Nucleinbasen oder ihren Nucleosidderivaten in wäßrigen Lösungen

  • Anorganische Und Physikalische Chemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary

The mutual interactions of Gd(III)tetraphenylporphyrin (GdTPP), Gd(III)tetramethylpyridylporphyrin (GdTMePyP), and the free base tetramethylpyridylporphyrin (H2 TMePyP) with some nucleic bases (adenine, thymine, uracil, and cytosine) and their N-glycoside derivatives (adenosine, thymidine, uridine, and cytidine) have been studied by spectrophotometric titration in mixed methanol-ammonia-water solutions. It has been found that tetramethylpyridylporphyrin and its gadolinium complex form 1:1 complexes with nucleic bases and their nucleoside derivatives. The equilibrium constants were estimated using curve fitting procedures. The interactions are stronger for nucleoside derivatives than for nucleic bases. They are also stronger for metallated than for non-metallated porphyrins.

Zusammenfassung

Die Wechselwirkungen von Gd(III)tetraphenylporphyrin (GdTPP), Gd(III)-tetramethylpyridylprophyrin (GdMePyP) und der freien Base Tetramethylpyridylporphyrin (H2 TMePyP) mit einigen Nucleinbasen (Adenin, Thymin, Uracil, Cytosin) und ihren N-glycosidierten Derivaten (Adenosin, Thymidin, Uridin, Cytidin) wurden in Methanol-Ammoniak-Wasser — Mischungen mittels spektrophotometrischer Titration untersucht. Tetramethylpyridylporphyrin und sein Gadoliniumkpomplex bilden 1:1-Komplexe mit Nucleinbasen und ihren Nucleosidderivaten. Die Gleichgewichtskonstanten wurden übercurve-fitting - Algorithmen bestimmt. Die Wechselwirkungen sind für Nucleosidderivate stärker als für Nucleinbasen und für metallierte Porphyrine stärker als für nichtmetallierte.

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Authors and Affiliations

  1. Department of Chemistry, Maria Curie-Sklodowska University, PL-20031, Lublin, Poland

    S. Radzki

  2. Laboratorie de Chimie des Substances Naturelles, Université de Limoges, F-87060, Limoges Cedex, France

    P. Krausz

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  1. S. Radzki
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Radzki, S., Krausz, P. Complex formation between gadolinium(III) porphyrins and some nucleic bases or their nucleoside derivatives in aqueous solutions. Monatsh Chem 127, 51–61 (1996). https://doi.org/10.1007/BF00807408

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  • DOI: https://doi.org/10.1007/BF00807408

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