Catalysis Letters

, Volume 27, Issue 1–2, pp 235–240 | Cite as

Enzymatic esterification and transesterification of N-protected Glu or Asp and synthesis of sweetener aspartam analogues by a new glutamic acid specific endopeptidase

  • Valérie Rolland-Fulcrand
  • René Lazaro
  • Philippe Viallefont


Esterification and transesterification reactions are carried out in water miscible organic solvents by using a new glutamic acid specific endopeptidase, isolated from Bacillus lichenifonnis. Sweetener aspartam analogues syntheses are also described.


glutamic acid specific endopeptidase (BL-GSE) esterification transesterification peptide synthesis sweetener aspartam analogues 


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Copyright information

© J.C. Baltzer AG, Science Publishers 1994

Authors and Affiliations

  • Valérie Rolland-Fulcrand
    • 1
  • René Lazaro
    • 1
  • Philippe Viallefont
    • 1
  1. 1.Laboratory of Aminoacids and Peptides, URA 468Montpellier II UniversityMontpellier Cedex 5France

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