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S-[2-Carboxy-1-(1H-imidazol-4-yl)ethyl]cysteine in normal human urine

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Summary

A compound, which had the same mobility on a high-voltage paper electrophoretogram and the sameR F value on a thin-layer chromatogram as those ofS-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]cysteine (I), was partially purified from human urine by ion-exchange column chromatography. The compound gave a signal at m/z 260 on its FAB mass spectrum, which was assigned as MH+ of compound I. These results suggest that the urinary compound is compound I and it is a physiological precursor of 3-[(carboxymethyl)thio]-3-(1H-imidazol-4-yl)propanoic acid [Kinuta et al., (1991) Biochem J 275: 617–621].

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Kinuta, M., Masuoka, N., Yao, K. et al. S-[2-Carboxy-1-(1H-imidazol-4-yl)ethyl]cysteine in normal human urine. Amino Acids 1, 259–262 (1991). https://doi.org/10.1007/BF00806924

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  • DOI: https://doi.org/10.1007/BF00806924

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