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Relationship of amino acid sequence to immunological activity — syntheses and structure-activity relationships of thymosinβ 4 family

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Summary

Four peptides related to thymosinβ 4 family and its six fragments were synthesized by the solution method. Among them, the four peptides related to thymosinβ 4 family and its two fragments were found to have restoring activity on the impaired blastogenic response of T-lymphocytes isolated from uremic patients, but the other four fragments had no effect. Studies on the structureactivity relationships suggest that the tricosapeptide moiety corresponding to amino acids 16–38 of thymosinβ 4 is found to be an important moiety on impaired immunological deficiency.

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Authors and Affiliations

  1. Kidney Research Laboratory, Kojinkai, 1-6, Tsutsujigaoka 2-chome, Miyagino-Ku, 980, Sendai, Japan

    T. Abiko & H. Sekino

Authors
  1. T. Abiko
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  2. H. Sekino
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Additional information

Amino acids and their derivatives used in this investigations were of the L-configuration. The following abbreviations are used: DMF, dimethylformamide; DMSO, dimethylsulfoxide; Boc, tert-butoxycarbonyl; Z, benzyloxycarbonyl; NP, p-nitrophenyl; ONp, p-nitrophenyl ester; OBzl, benzyl ester; Bzl, benzyl; Troc,β,β,β-tricloroethoxycarbonly; Su, N-hydroxysuccinimide; NMM, N-methylmorpholine; OSu, N-hydroxysuccinimide ester; WSCI, l-ethyl-3; (3-dimethylaminopropyl) carbodiimide; HOBT, N-hydroxybenzotriazole; TFA, trifluoroacetic acid; TLC, thin-layer chromatography; E-rosette, a rosette with sheep erythrocytes; EDTA, ethylenediaminetetraacetic acid; PHA, phytohemagglutinin; HPLC, high-performance liquid chromatography; ONb, p-nitrobenzyl ester; DCC, dicyclohexyl-carbodiimide.

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Abiko, T., Sekino, H. Relationship of amino acid sequence to immunological activity — syntheses and structure-activity relationships of thymosinβ 4 family. Amino Acids 1, 215–223 (1991). https://doi.org/10.1007/BF00806919

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  • DOI: https://doi.org/10.1007/BF00806919

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