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Effect of formaldehyde and its aminomethylol derivatives on strains ofEscherichia coli with various defects of DNA repair systems

  • Experimental Genetics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Aminomethylol compounds formed by the reaction between formaldehyde and amino acids, like formaldehyde itself, have a marked lethal action on strains ofEscherichia coli with various defects of DNA repair systems. Correlation was found between the degree of depurinization of DNA caused by different aminomethylol derivativesin vitro and the inactivating action of these derivatives on bacteria. It is suggested on the basis of the results that the inactivating effect of formaldehyde and its aminomethylol derivatives is evidently due to the formation of depurinized regions in the bacterial DNA rather than to dimerization of the purine bases.

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Authors
  1. E. V. Mitsevich
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  2. Yu. A. Semin
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  3. A. M. Poverennyi
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  4. Yu. G. Suchkov
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Mitsevich, E.V., Semin, Y.A., Poverennyi, A.M. et al. Effect of formaldehyde and its aminomethylol derivatives on strains ofEscherichia coli with various defects of DNA repair systems. Bull Exp Biol Med 87, 489–491 (1979). https://doi.org/10.1007/BF00806692

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  • DOI: https://doi.org/10.1007/BF00806692

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