Mechanism of regression of mammary gland carcinoma in lactating rats

  • N. D. Lagova


The effect of the conditions of lactation on the frequency of regression of a transplantable mammary gland carcinoma RMK-1 was studied in albino rats. In rats feeding 8±1 young the tumor underwent regression in 47% of cases. After ovariectomy and administration of cortisone and oxytocin, which have an indirect inhibitory action on the secretion of FSH by the pituitary, the frequency of regression of tumors in rats feeding the same number of young rose to 71–81%. In rats with prolonged lactation, feeding 8±1 young for 2–2.5 months, and in rats with intensive lactation feeding litters of 13±2 young, regression of the tumors did not increase. The results confirm the validity of the hypothesis that, besides high secretion of pituitary FSH, a decrease in the secretion of pituitary LH plays a role in the regression of mammary gland carcinoma in the course of lactation.

Key Words

carcinoma regression lactation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    I. I. Grachev and V. P. Galantsev, The Physiology of Lactation, General and Comparative [in Russian], Leningrad (1973).Google Scholar
  2. 2.
    N. D. Lagova, in: Hormone Therapy of Malignant Tumors (N. I. Lazarev, ed.) [in Russian], Moscow (1968), pp. 48–69.Google Scholar
  3. 3.
    N. D. Lagova, I. S. Burenin, A. P. Chebyshev, et al., Proceedings of the 7th Scientific Conference to Review Work at the Institute of Experimental and Clinical Oncology, Academy of Medical Sciences of the USSR, [in Russian], Moscow (1971), pp. 114–117.Google Scholar
  4. 4.
    N. D. Lagova and V. V. Il'yashenko, Byull. Éksp. Biol. Med., No. 2, 81 (1971).Google Scholar
  5. 5.
    N. D. Lagova, V. V. Samoilov, and M. G. Goncharova, Probl. Éndokrinol., No. 2, 97 (1966)Google Scholar
  6. 6.
    N. I. Lazarev, Theoretical Basis of the Prevention and Treatment of Dyshormonal Tumors [in Russian], Moscow (1963).Google Scholar
  7. 7.
    K. Yoshinaga, Colloq. Int. C. N. R. S.,168, 273 (1968).Google Scholar
  8. 8.
    G. M. McCormick and R. C. Moon, Br. J. Cancer,19, 160 (1965).Google Scholar
  9. 9.
    F. Mena et al., Endocrinology,82, 623 (1968).Google Scholar
  10. 10.
    J. Mishinsky, K. Khezen, and F. G. Sulman, Endocrinology,82, 611 (1968).Google Scholar
  11. 11.
    I. Rotchild, Endocrinology,67, 9 (1960).Google Scholar
  12. 12.
    A. A. Simpson, M. H. W. Simpson, and P. N. Kulkarni, J. Endocrinol.,57, 425 (1973).Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • N. D. Lagova

There are no affiliations available

Personalised recommendations