Abstract
The investigation was carried out on male CBA mice using the casein model of amyloidosis. After simultaneous transplantation of fragments of spleen from intact and amyloid donors beneath the capsule of opposite poles of the kidney into intact and amyloid recipients, deposits of amyloid both in the endogenous spleen and in the graft from intact donors were found in 40% of intact animals. In amyloid recipients under observation for periods of between 5 days and 6 months, deposits of amyloid in the intact graft were observed in only 5% of cases. It is postulated that amyloidosis is “transferred” through migration of cells participating in amyloid formation and that this mechanism is inhibited in animals with amyloidosis.
Similar content being viewed by others
Literature Cited
V. V. Sura, V. V. Serov, M. P. Chebyshev, et al., Byull. Éksp. Biol. Med., No. 12, 95 (1974).
F. Hardt et al., Clin. Exp. Immunol.,10, 487 (1972).
F. Hardt and P. Ranlov, Acta Pathol. Microbiol. Scand.,73, 549 (1968).
F. Hardt, Acta Pathol. Microbiol. Scand.,79A, 61 (1971).
D. T. Janingan and R. L. Druet, Am. J. Pathol.,52, 381 (1968).
P. Ranlov and O. Werdelin, Acta Pathol. Microbiol. Scand.,70, 249 (1967).
M. Soborg and G. Bendixen, Acta Med. Scand.,181, 247 (1967).
O. Werdelin and P. Ranlov, Acta Pathol. Microbiol. Scand.,72, 13 (1968).
Rights and permissions
About this article
Cite this article
Sura, V.V., Osipova, I.N., Chebyshev, A.P. et al. Amyloid transfer from a syngeneic graft of amyloid spleen in intact and amyloid mice. Bull Exp Biol Med 85, 826–829 (1978). https://doi.org/10.1007/BF00806179
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00806179