Abstract
Thermostable antigens (TA) were found by the gel precipitation test and by immunoelectrophoresis in malignant tumors of muscle tissue induced by dimethylbenzanthracene, and in the amniotic fluid of 8–12-day embryos and certain normal organs of adult Wistar rats. Relative tissue specificity of these antigens was demonstrated, on the one hand, for tumors, amniotic fluid, and the uterus, and on the other hand for the lung, spleen, and serum. TA detected in tumors and amniotic fluid by immunoelectrophoresis are located in the zones of α- and α1-globulins.
Similar content being viewed by others
Literature Cited
V. G. Galaktionov, N. Yu. Alekseeva, V. Ya. Arion, et al., in: The Role of Stem Cells in Leukemogenesis and Carcinogenesis. Abstracts of Proceedings of a Symposium [in Russian], Kiev (1977), p. 60.
I. I. Kolker, S. M. Vun', and M. A. Grigor'eva, Byull. Éksp. Biol. Med., No. 2, 204 (1976).
M. S. Lomakin, V. L. Levitina, and A. S. Larin, Byull. Éksp. Biol. Med., No. 11, 70 (1975).
R. M. Burton, N. J. Hope, and L. Lubbers, Am. J. Obstetr. Gynecol.,125, 472 (1976).
A. H. Glasgow, S. R. Cooperband, and J. A. Mannick, Fed. Proc.,31, 803 (1972).
B. B. Kamrin, Ann. New York Acad. Sci.,73, 848 (1958).
A. B. Karpas and D. Segre, Proc. Soc. Exp. Biol. (New York),144, 141 (1973).
B. A. McErlean, Nature,197, 507 (1963).
R. A. Murgita and T. B. Tomasi, J. Exp. Med.,141, 269 (1975).
R. A. Murgita et al., J. Exp. Med.,141, 440 (1975).
Rights and permissions
About this article
Cite this article
Lomakin, M.S., Larin, A.S. & Maiskii, I.N. Thermostable antigens of malignant tumors and normal tissues of experimental animals. Bull Exp Biol Med 85, 795–798 (1978). https://doi.org/10.1007/BF00806170
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00806170