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Correlation between leukocyte migration activity and RNA and DNA synthesis in experiments in vitro

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In a parallel study of leukocyte migration in vitro in the presence of specific antigen and spontaneous synthesis of RNA and DNA the following significant correlations were found in lymphocytes in culture: 1) direct correlation between RNA and DNA synthesis; 2) close correlation between antigen-induced migration and the levels of RNA and DNA synthesis. The effect of the antigen was manifested as inhibition or stimulation of leukocyte migration. A high ratio between RNA synthesis and DNA synthesis corresponded to inhibition of migration, a low ratio to its stimulation. The value of the ratio itself varied mainly on account of changes in the level of DNA synthesis. The participation of T and B lymphocytes in the regulation of leukocyte mobility under the influence of antigen is discussed.

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Authors
  1. P. G. Nazarov
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  2. A. P. Volgarev
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  3. S. A. Ermakov
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Nazarov, P.G., Volgarev, A.P. & Ermakov, S.A. Correlation between leukocyte migration activity and RNA and DNA synthesis in experiments in vitro. Bull Exp Biol Med 85, 790–791 (1978). https://doi.org/10.1007/BF00806168

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  • DOI: https://doi.org/10.1007/BF00806168

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