Skip to main content
SpringerLink
Log in

Bound immunoglobulins of classes M, A, and G studied in the thymus of patients with myasthenia gravis

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Deposits of granular material containing immunoglobulins (Ig) of the M, A, and G classes, were found by direct immunofluorescence in the thymus of patients with myasthenia. Treatment of sections of the thymus of myasthenic patients with unlabeled preparations against individual classes of human Ig inhibits the reaction of the granular material with homologous labeled preparations. Disappearance of fluorescence of the deposits also was observed in sections treated with glycine-HCl buffer, pH 2.8. These results suggest that the granular material consists of immune complexes in which IgM, IgA, and IgG act as antibodies and components of the thymus tissues as the antigen. The presence of bound Ig in the thymus is evidence that in myasthenia an autoimmune process directed against the tissues of this organ is involved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literature Cited

  1. L. V. Beletskaya and E. V. Gnezditskaya, Usp. Sovrem. Biol.,79, No. 1, 128 (1975).

    Google Scholar 

  2. E. V. Gnezditskaya, L. V. Beletskaya, and D. I. Shagal, Byull. Éksp. Biol. Med., No. 4, 85 (1974).

    Google Scholar 

  3. E. V. Gnezditskaya, L. V. Beletskaya, and D. I. Shagal, Byull. Éksp. Biol. Med., No. 1, 60 (1977).

    Google Scholar 

  4. S. Avrameas and T. Ternynck, Immunochemistry,6, 53 (1969).

    Google Scholar 

  5. J. S. Baumstark, R. J. Laffin, and W. A. Bardawil, Arch. Biochem.,108, 514 (1964).

    Google Scholar 

  6. F. M. Burnet and J. R. Mackay, Lancet,2, 1030 (1962).

    Google Scholar 

  7. R. van Furth, H. R. E. Smith, and W. Hijmans, Immunology,11, 19 (1966).

    Google Scholar 

  8. H. W. R. van der Geld, T. E. Feltkamp, et al., Proc. Soc. Exp. Biol. (New York),115, 782 (1964).

    Google Scholar 

  9. G. Goldstein, Lancet,2, 1164 (1966).

    Google Scholar 

  10. R. Mori et al., Lancet,1, 210 (1973).

    Google Scholar 

  11. R. G. White and A. H. E. Marshall, Lancet,2, 120 (1962).

    Google Scholar 

Download references

Authors
  1. É. V. Gnezditskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. V. Beletskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. Kh. Ippolitov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. I. Shagal
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gnezditskaya, É.V., Beletskaya, L.V., Ippolitov, I.K. et al. Bound immunoglobulins of classes M, A, and G studied in the thymus of patients with myasthenia gravis. Bull Exp Biol Med 85, 776–779 (1978). https://doi.org/10.1007/BF00806163

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00806163

Key Words

Search

Navigation