Abstract
It was shown by means of the indirect macrophage migration inhibition test in the H-2 system, using fractionated lymphocytes, that macrophage inhibition factor (MIF) is produced by T but not by B cells. Cells producing MIF are more sensitive to the action of anti-θ-antibodies than T-killer cells. MIF formation by lymph node cells was detected at earlier periods after immunization than the cytotoxic activity of these cells. The results obtained are evidence of differences between the subpopulation of T cells synthesizing MIF and cytotoxic T lymphocytes.
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Suslov, A.P., Brondz, B.D. & Egorova, S.G. Properties of T cells synthesizing macrophage migration inhibition factor in the H-2 system. Bull Exp Biol Med 85, 766–769 (1978). https://doi.org/10.1007/BF00806160
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DOI: https://doi.org/10.1007/BF00806160