Abstract
The sensitivity to pain of mice of congenitally resistant (CR) strains based on A/Sn, C3H/Sn, and C57BL/10/Sn strains was studied after injection of morphine into the animals. Among the CR strains based on A/Sn and C3H/Sn, strains sensitive and resistant to the narcotic were distinguished. Sensitivity to morphine is inherited as a dominant. The possibility of the participation of the principal H-2 histocompatibility system in mice in the genetic control of the sensitivity of mice to morphine is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
P. Ivani and I. K. Egorov, Immunogenetics of Tissue Compatibility (HLA and H-2) [in Russian], Moscow (1975).
C. Castellano, U. Filibak, and A. Oliverio, Psychopharmacologia (Berlin),49, 23 (1976).
N. B. Eddy and D. Leimbach, J. Pharmacol. Exp. Ther.,107, 385 (1953).
A. Oliverio, C. Castellano, and B. E. Eleftheriou, Psychopharmacologia (Berlin),42, 219 (1975).
L. Shuster, S. W. Webster, G. Yu, et al., Psychopharmacologia (Berlin),42, 249 (1975).
S. H. Snyder, Nature,257, 185 (1975).
Rights and permissions
About this article
Cite this article
Maiskii, A.I., Vedernikova, N.N. & Volov, V.A. Role of the H-2 system in regulating the sensitivity of mice to morphine. Bull Exp Biol Med 85, 752–754 (1978). https://doi.org/10.1007/BF00806155
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00806155