Skip to main content
SpringerLink
Log in

Pattern of hyperlipidemia in rats with chronic renal failure

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The character of the hyperlipidemia was studied in rats with chronic uremia caused by removal of five-sixths of the total weight of kidney tissue. The blood cholesterol and phospholipid concentrations were almost twice the normal level 13–30 days after subtotal nephrectomy in the rats with uremia. The hyperlipidemia was more marked when the blood nonprotein nitrogen level was high. The serum triglyceride concentration was not increased. The total concentration of serum β-and pre-β-lipoproteins, determined nephelometrically, was significantly increased only if the nonprotein nitrogen exceeded 80 mg%. Disk electrophoresis of the serum lipoproteins of the rats with uremia revealed a definite increase in the α-lipoprotein concentration and a very small increase in the β-lipoprotein concentration. Postheparin plasma lipolytic activity in the rats with uremia was normal. Massive proteinuria was observed in the experimental rats, but the hypoproteinemia was not significant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. M. Ledvina, Lab. Delo, No. 3, 13 (1960).

    Google Scholar 

  2. N. V. Nikiforova, I. V. Sokolovskaya, V. M. Ermolenko, et al., Ter. Arkh., No. 4, 76 (1975).

    Google Scholar 

  3. A. A. Pokrovskii (editor), Clinical Biochemical Methods of Investigation [in Russian], Moscow (1969), p. 311.

  4. J. D. Bagdade, E. Yee, and D. E. Wilson, Clin. Res.,23, 314A (1975).

    Google Scholar 

  5. J. D. Bagdade, A. Casaretto, and J. Albers, J. Lab. Clin. Med.,87, 37 (1976).

    Google Scholar 

  6. L. A. Carlson, J. Atheroscler. Res.,3, 334 (1963).

    Google Scholar 

  7. J. Folch, M. Lees, and G. H. Sloane-Stanley, J. Biol. Chem.,226, 497 (1957).

    Google Scholar 

  8. J. C. La Rose, R. J. Levy, P. Herbert, et al., Biochem. Biophys. Res. Commun.,41, 57 (1970).

    Google Scholar 

  9. A. Lindner, B. Charra, and D. J. Sherrard, New Engl. J. Med.,290, 697 (1974).

    Google Scholar 

  10. E. J. McCosh, K. Solangi, J. M. Rivers, et al., Am. J. Clin. Nutr.,28, 1036 (1975).

    Google Scholar 

  11. A. B. Morrison, Lab. Invest.,11, 321 (1962).

    Google Scholar 

  12. K. A. Narayan, H. L. Greinin, and F. A. Kummerow, J. Lipid Res.,7, 150 (1966).

    Google Scholar 

  13. K. A. Narayan, Atherosclerosis,13, 205 (1971).

    Google Scholar 

  14. W. Romen and W. D. Heine, Arch. Pathol. Anat. Abt. A,356, 42 (1972).

    Google Scholar 

  15. T. Shimamura, Exp. Mol. Pathol.,13, 79 (1970).

    Google Scholar 

Download references

Authors
  1. N. V. Nikiforova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. K. Tananaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. L. Pozdnyakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. V. Sokolovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nikiforova, N.V., Tananaeva, I.K., Pozdnyakov, A.L. et al. Pattern of hyperlipidemia in rats with chronic renal failure. Bull Exp Biol Med 85, 738–742 (1978). https://doi.org/10.1007/BF00806151

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00806151

Key Words

Search

Navigation