Advertisement

Effect of electrical stimulation of the supraoptic region of the hypothalamus on lipid metabolism and the development of atherosclerosis

  • I. S. Zavodskaya
  • E. V. Moreva
  • T. A. Sinitsyna
  • V. E. Ryzhenkov
  • N. G. Nikul'cheva
  • I. V. Mosina
Pathological Physiology and General Pathology
  • 20 Downloads

Abstract

Electrical stimulation of the supraoptic region of the hypothalamus for 3 weeks in rabbits kept for 3–8 weeks on an atherogenic diet accelerates and intensifies the development of hypercholesteremia and lipoidosis of the coronary arteries and also the metabolic disturbances in the myocardial tissue. These last disturbances are expressed as a fall in the tissue noradrenalin and creatine phosphate concentration and an increase in the inorganic phosphorus and lactic acid concentration.

Key Words

hypothalamus coronary arteries electrical stimulation lipid metabolism atherosclerosis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    M. L. Belen'kii, Elements of Quantitative Evaluation of a Pharmacological Effect [in Russian], Leningrad (1963).Google Scholar
  2. 2.
    A. M. Vikhert, Ter. Arkh., No. 2, 107 (1973).Google Scholar
  3. 3.
    V. K. Gorodetskii, in: Modern Methods in Biochemistry, (ed. by V. N. Orekhovich) [in Russian], Vol. 1, Moscow (1964), p. 311.Google Scholar
  4. 4.
    É. Sh. Matlina and T. B. Rakhmanova, in: Methods of Investigation of Some Systems of Humoral Regulation [in Russian], Moscow (1967), pp. 136–141.Google Scholar
  5. 5.
    É. Ya. Preimate, in: Medical Scientists of the Latvian SSR — Medical Practice [in Russian], Part 1, Riga (1975), p. 68.Google Scholar
  6. 6.
    I. Ya. Usvatova and Yu. A. Tankov, in: Modern Methods of Determination of Steroid Hormones in Biological Fluids [in Russian], Moscow (1968), pp. 38–48.Google Scholar
  7. 7.
    L. L. Abell, B. B. Levy, B. B. Brodie, et al., J. Biol. Chem.,195, 357 (1952).Google Scholar
  8. 8.
    S. B. Barker and W. H. Summerson, J. Biol. Chem.,138, 535 (1941).Google Scholar
  9. 9.
    L. A. Carlson, J. Atheroscler. Res.,3, 334 (1963).Google Scholar
  10. 10.
    A. Ennor and H. Rosenberg, Biochem. J.,51, 606 (1952).Google Scholar
  11. 11.
    C. H. Fiske and I. Subbarow, J. Biol. Chem.,66, 375 (1925).Google Scholar
  12. 12.
    W. H. Gutstein et al., Ann. New York Acad. Sci.,275, 117 (1976).Google Scholar
  13. 13.
    K. Itaya and M. Ui, J. Lipid Res.,6, 16 (1965).Google Scholar
  14. 14.
    C. H. Sawyer, J. W. Everett, and J. D. Green, J. Comp. Neurol.,101, 801 (1954).Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • I. S. Zavodskaya
  • E. V. Moreva
  • T. A. Sinitsyna
  • V. E. Ryzhenkov
  • N. G. Nikul'cheva
  • I. V. Mosina

There are no affiliations available

Personalised recommendations