Abstract
In experiments on male rats the activity of the pituitary-adrenal system was studied after electrolytic destruction of different parts of the hypothalamus. Pharmacological analysis demonstrated the irregular distribution of cholinergic and adrenergic systems controlling the secretion of ACTH and glucocorticoids in the hypothalamus. It is suggested that the cholinergic systems are located in the mammillary region, α-adrenergic systems in the region of the anterior or posterior hypothalamus, and β-adrenergic receptors in the region of the ventromedial nuclei of the hypothalamus. The latter perhaps play an inhibitory role.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
B. V. Aleshin, The Histophysiology of the Hypothalamic-Hypophyseal System [in Russian], Moscow (1971).
M. L. Belen'kii, Elements of Quantitative Evaluation of a Pharmacological Effect [in Russian], Riga (1959).
N. A. Losev and V. A. Lapkin, Farmakol. Toksikol., No. 1, 18 (1975).
A. F. Makarchenko, R. S. Zlatin, and B. A. Roitrub, in: Problems in Physiology and the Hypothalamus [in Russian], No. 7, Kiev (1973), pp. 46–48.
M. I. Mityushov et al., The Pituitary—Adrenal System and the Brain [in Russian], Leningrad (1976), p. 208.
A. N. Poskalenko, in: The Pharmacology of New Sedatives and Their Clinical Application [in Russian], Leningrad (1962), pp. 129–134.
A. N. Poskalenko, “The character and mechanism of action of cholinergic drugs on the hypothalamic-hypophyseal-adrenal system,” Doctoral Dissertation, Leningrad (1965).
N. S. Sapronov and V. E. Ryzhenkov, Probl. Éndokrinol., No. 4, 47 (1975).
I. Ya. Usvatova and Yu. A. Pankov, in: Modern Methods of Determination of Steroid Hormones in Biological Fluids [in Russian], Moscow (1968), pp. 38–48.
F. R. Khalikova and S. Kh. Nasirov, in: The Pharmacology of Plant Substances [in Russian], Tashkent (1973), pp. 5–16.
A. Brodish, Endocrinology,74, 28 (1964).
W. F. Ganong, in: Brain-Endocrine Interaction. Median Eminence: Structure and Function, Basel (1972), p. 254.
J. F. R. Konig and R. A. Klippel, The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem, Baltimore (1963).
O. Lindvall and A. Bjorklund, Acta Physiol. Scand., Suppl. 412, 1 (1974).
D. L. Margules and A. Margules, Am. J. Physiol.,224, 1475 (1973).
Rights and permissions
About this article
Cite this article
Sapronov, N.S., Khnychenko, L.K. Role of the cholinergic and adrenergic systems of the hypothalamus in the regulation of pituitary adrenocorticotrophic function. Bull Exp Biol Med 85, 704–707 (1978). https://doi.org/10.1007/BF00806141
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00806141