Summary
Utilization of intravenously administered alanyl-L-glutamine and glycyl-L-glutamine as a source of glutamine was tested in growing rats receiving total parenteral nutrition for 15 days. In experiment A the two peptides were compared to each other, in experiment B alanyl-L-glutamine was compared to an equimolar mixture of free alanine and glutamine, and in experiment C glycyl-L-glutamine was tested against an equimolar mixture of free glycine and glutamine.
There was no difference of statistical significance in weight gain or nitrogen balance between the respective groups participating in the 3 experiments. Plasma levels of free glutamine were similar during infusion with alanyl-L-glutamine or glycyl-L-glutamine. The daily urinary excretion rate recorded for alanyl-L-glutamine was 3.7% and for glycyl-L-glutamine 4.3% of the infused amount. The results show that both peptides are utilized for protein synthesis and growth to approximately the same as the corresponding free amino acids.
Similar content being viewed by others
References
Adibi SA (1987) Inf Ther Clin Nutr 17: 69–90
Adibi SA, Paleos GA, Morse EL (1986) Metabolism 35: 830–836
Ardawi MSM (1988) Metabolism 37: 99–103
Askanazi J, Carpentier YA, Michelsen CB, Elwyn DH, Fürst P (1980) Ann Surg 192: 78–85
Aulick LH, Wilmore DW (1979) Surgery 85: 560–565
Biotronik, Wissenschaftliche Geräte GmbH (1983) Biotronik Handbuch LC 5000, München
Brandl M, Sailer D, Langer K, Engelhardt A, Kleinhenz H, Adibi SA, Fekl W (1987) Inf Ther Clin Nutr 17: 103–106
Caldwell MD (1939) Metabolism 38 [Suppl 1]: 34–39
Fürst P (1985) Nutrition in cancer and trauma sepsis. Karger, Basel, pp 21–53
Fürst P, Albers S, Stehle P (1987) Inf Ther Clin Nutr 17: 117–136
Fürst P, Bergström J, Chao L, Larsson J, Liljedahl SO, Neuhäuser M, Schildt B, Vinnars E (1979) Acta Chir Scand 494 [Suppl]: 136–138
Gamrim L, Hultman E, Vinnars E, Wernerman J (1991) Clin Nutr 10 [Suppl 2]: 28
Hwang LD, O'Dwyer ST, Smith RJ (1986) Surg Forum 37: 56–58
Jacobs D, Evans DA, O'Dwyer ST, Smith RJ, Wilmore DW (1988) J Parent Ent Nutr 12 [Suppl]: 68
Johnson LR, Copeland EM, Dudrick SJ, Lichtenberger LM, Castro GA (1975) Gastroenterology 68: 1177–1183
Karner J, Roth E, Karner-Hanusch J, Kovats E, Fürst P, Funovics J, Fritsch A (1987) Inf Ther Clin Nutr 17: 137–143
Magnusson I, Kihlberg R, Ekman L, Wahren J (1987) Clin Nutr 6 [Suppl]: 31
Muhlbacher F, Kapadia CR, Colpoys MF, Smith JR, Wilmore DW (1984) Am J Physiology 247: E75-E83
Neuhäuser M, Göttmann U, Bässler KH (1984) Infusionstherapie 11: 175–180
Neuhäuser M, Wandira JA, Göttmann U, Bässler KH (1985) Am J Clin Nutr 42: 585–596
Neuhäuser M, Bässler KH (1986) Infusionstherapie 13: 292–296
Neuhäuser M, Grötz KA, Wandira JA, Bässler KH, Langer K (1986) Metabolism 35: 869–873
Neuhäuser-Berthold M, Kuhfus A, Bässler KH (1988a) Metabolism 37: 796–801
Neuhäuser-Berthold M, Pässler S, Berthold D, Bässler KH (1988b) J Parent Ent Nutr 12: 148
Neuhäuser-Berthold M, Pässler S, Grünfeld A, Berthold D, Bässler KH (1988c) Clin Nutr 7 [Suppl]: 73
Neuhäuser-Berthold M, Wirth S, Hellmann U, Bässler KH (1988d) Clin Nutr 7: 145–150
Newsholme EA, Newsholme P, Curi R, Challoner E, Ardawi MSM (1988) Nutr 4: 261–268
Roth E, Funovics J, Mühlbacher F, Schemper M, Mauritz W, Sporn P, Fritsch A (1982) Clin Nutr 1: 25–41
Steinhardt HJ, Paleos GA, Brandl M, Fekl WL, Adibi SA (1984) Gastroenterology 86: 1562–1569
Ward MWN, Owens CW, Rennie MJ (1980) Clin Chem 26: 1336–1339
Windmueller HG (1982) Advances Enzym 53: 201–237
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Neuhäuser-Berthold, M., Eufinger, H. Utilization of alanyl-L-glutamine and glycyl-L-glutamine during long-term parenteral nutrition in the growing rat. Amino Acids 3, 293–302 (1992). https://doi.org/10.1007/BF00806004
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00806004