Bulletin of Experimental Biology and Medicine

, Volume 44, Issue 6, pp 1491–1495 | Cite as

The influence of some derivatives of the phenothiazine group on reflexes from the heart

  • M. Yu. Ladinskaya
Pharmacology
  • 13 Downloads

Summary

Short-term experiments were performed on anesthetized and decerebrate cats. A comparative study was carried out on the effect of aminazine and mepazine on the reflex reactions when cardiac blood supply was impaired.

It was established that mepazine and aminazine depressed the reflexes from the heart and decreased the electrocardiographic changes. The effect of aminazine on the reflexes from the heart is more pronounced than that of mepazine.

The latter completely eliminates the changes in the electrocardiogram connected with disturbance of coronary circulation. In the case of aminazine this property is almost absent. In combined administration of mepazine and analgesic substances (phenadon, promedol) the effect of these preparations is considerably prolonged.

Keywords

Public Health Blood Supply Phenothiazine Coronary Circulation Combine Administration 

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Literature Cited

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    V. V. Zakusov and N. V. Kaverina, Sovet. Med., 10, 3–8 (1956).Google Scholar
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    M. Yu. Ladinskaya, Farmakol. i Toksikol. (In press).Google Scholar
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    H. Kleinsorge and K. Rosner, Die Phenothiazinderivate in der inneren Medizin, Jena, (1956).Google Scholar

Copyright information

© Consultants Bureau, Inc. 1958

Authors and Affiliations

  • M. Yu. Ladinskaya
    • 1
  1. 1.Laboratory of Regional Pharmacology, Institute of Pharmacology and ChemotherapyAMN SSSRMoscow

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