Abstract
Experiments were carried out on 40 male albino rats after whole-body irradiation in a dose of 200 R to study the effect of thymarin, a preparation obtained from bovine thymus and consisting of a combination of three fractions of physiologically active polypeptides with a mean molecular weight of about 10,000 on the course of local wound healing after cryosurgical destruction of the mucous membrane of the hard palate. Thymarin was injected subcutaneously daily for 10 days after cryosurgical destruction. The experimental results reveal a beneficial effect of thymarin on the course of regeneration and, in particular, more rapid sloughing of necrotic tissues, a shortening of the period of epithelization of the wound surface, and prevention of the development of secondary infection.
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Solov'ev, M.M., Vasil'ev, A.V., Morozov, V.G. et al. Effect of physiologically active substances isolated from the thymus on wound healing after cryosurgical destruction in rats. Bull Exp Biol Med 84, 1341–1344 (1977). https://doi.org/10.1007/BF00805902
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DOI: https://doi.org/10.1007/BF00805902