Bulletin of Experimental Biology and Medicine

, Volume 84, Issue 3, pp 1328–1330 | Cite as

Induction of transmissible leukemia-like syndromes in mice by injection of antigens and immunostimulants

  • J. Denner


Splenomegaly characterized by myeloid metaplasia was induced in BALB/c mice by injection of antigens and immunostimulants. By contrast with the leukemoid reaction, this syndrome can be transmitted by both plasma and spleen cells. Small virus-like particles (30–50 nm) were found in the plasma and RNA-containing type C viruses in the spleen cells.

Key Words

splenomegaly myeloproliferation retraviruses small virus-like particles 


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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • J. Denner

There are no affiliations available

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