Abstract
The effect of phentolamine on the volume velocity of the cerebral blood flow, tone of the cerebral vessels, and partial pressure of oxygen in the brain tissue was studied in acute experiments on anesthetized and unanesthetized cats. Intravenous injection of phentolamine led to a prolonged fall of blood pressure and of the tone of the intracranial and, to a lesser degree, the extracranial vessels. The volume velocity of the cerebral blood flow was reduced in animals with marked phentolamine hypotension.If the perfusion pressure was stabilized, the blood flow was increased. Changes in pO2 in the brain tissue corresponded largely to the blood flow. Preliminary atropinization and denervation of the carotid zones did not alter the effect of phentolamine. Phentolamine reduced or abolished the constrictor action of noradrenalin and phenylephrine on the brain vessels.
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Literature Cited
M. D. Gaevyi, Fiziol. Zh. (Ukr.), No. 3, 417 (1967).
M. D. Gaevyi, Fiziol. Zh. SSSR, No. 7, 891 (1969).
M. D. Gaevyi and S. P. Trofimenko, Fiziol. Zh. SSSR, No. 10, 1457 (1970).
L. N. Dadiani and L. S. Andreeva,Patol. Fiziol., No. 3, 91 (1972).
G. I. Mchedlishvili, L. G. Ormonadze, and G. V. Amashukeli, Byull. Éksp. Biol. Med., No. 10, 3 (1967).
V. M. Khayutin, Fiziol. Zh. SSSR, No. 7, 645 (1958).
A. Bernsmeier, Acta Neurol. Scand., Suppl. 5, 1 (1954).
B. Ekström-Jodal, C. Essen, and E. Häggendal, Acta Neurol. Scand.,50, 11 (1974).
U. Gottstein, Der Hirnkreislauf unter dem Einfluss vasoaktiver Substanzen, Heidelberg (1962).
R. A. Lende, J. Neurosurg.,17, 90 (1960).
G. D. Louis, Stroke,4, 30 (1973).
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Mal'tsev, V.G., Gaevyi, M.D. Effect of phentolamine on the cerebral circulation. Bull Exp Biol Med 84, 1283–1285 (1977). https://doi.org/10.1007/BF00805885
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DOI: https://doi.org/10.1007/BF00805885