Abstract
The effect of the central cholinolytic benactyzine (40 mg/kg) and of the cholinomimetic arecoline (2.5 mg/kg) on activity of Mg2–-dependent ATPase was studied and the content of Ca2– and Mg2– ions determined in rat brain. Benactyzine and arecoline caused biphasic changes in the activity of the enzyme and content of the electrolytes. It is concluded that inhibition of the enzyme is linked with the accumulation of Ca2– ions and its activation with an increase in the concentration of Mg2– ions in brain tissue. It is suggested that benactyzine and arecoline exert their influence on the liberation and retention of neuromediators in the tissue depots through these effects.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
A. L. Bandman, L. V. Smirnova, and G. A. Sofronov, Byull. Éksp. Biol. Med., No. 7, 56 (1973).
R. N. Glebov and N. M. Dmitrieva, Biokhimiya, No. 4, 822 (1974).
N. R. Elaev, M. O. Karryeva, and M. P. Podosinovikova, Farmakol. Toksikol., No. 5, 632 (1972).
S. S. Krylov and E. A. Snegirev, Byull. Éksp. Biol. Med., No. 9, 49 (1970).
E. V. Semenov, A. N. Petrov, and M. P. Podosinovikova, Byull. Éksp. Biol. Med., No. 8, 42 (1975).
A. Carlsson, N. Hillarp, and B. Waldeck, Acta Physiol. Scand.,59, 1 (1963).
M. Hayvashi and I. Auditore, J. Neurochem.,11, 671 (1964).
O. H. Lowry, N. J. Rosebrough, A. L. Farr, et al., J. Biol. Chem.,193, 265 (1951).
H. Tischer and W. Oelssner, Acta Biol. Med. Germ.,18, 443 (1967).
T. Valcana and P. Timiras, J. Neurochem.,16, 935 (1969).
T. White, J. Neurochem.,24, 1037 (1975).
Rights and permissions
About this article
Cite this article
Semenov, E.V., Krylov, S.S. & Petrov, A.N. Effect of benactyzine and arecoline on Mg2–-ATPase activity and content of Ca2– and Mg2– ions in the rat brain. Bull Exp Biol Med 84, 1280–1283 (1977). https://doi.org/10.1007/BF00805884
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00805884